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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 1,2 are 70
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM0137
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    Altritol nucleic acid
    18
    1,2
    Sugar
    Sugar
    57 percent target mRNA inhibition
    19282453
    SM0138
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Guanidinoethyl
    Altritol nucleic acid
    18
    1,2
    Sugar
    Sugar
    56.1 percent target mRNA inhibition
    19282453
    SM0139
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid
    Altritol nucleic acid
    2,8,14,17
    1,2
    Sugar
    Sugar
    60.1 percent target mRNA inhibition
    19282453
    SM0140
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid
    Altritol nucleic acid
    5,8,14,17,22
    1,2
    Sugar
    Sugar
    40.4 percent target mRNA inhibition
    19282453
    SM0141
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGC
    Altritol nucleic acid* 2-Deoxy
    Altritol nucleic acid
    1,2 * 22
    1,2
    Sugar
    Sugar
    57.1 percent target mRNA inhibition
    19282453
    SM0142
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGC
    Altritol nucleic acid* 2-Deoxy
    Altritol nucleic acid
    18,19 * 22
    1,2
    Sugar
    Sugar
    51.6 percent target mRNA inhibition
    19282453
    SM0143
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGC
    Altritol nucleic acid* 2-Deoxy
    Altritol nucleic acid
    5,8,11,14,17 * 22
    1,2
    Sugar
    Sugar
    36.3 percent target mRNA inhibition
    19282453
    SM0144
    GACGUAAACGGCCACAAGUUCU
    ACUUGUGGCCGUUUACGUCGC
    Altritol nucleic acid
    Altritol nucleic acid
    20,21
    1,2
    Sugar
    Sugar
    36.7 percent target mRNA inhibition
    19282453
    SM0145
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid
    Altritol nucleic acid
    19,20
    1,2
    Sugar
    Sugar
    44.6 percent target mRNA inhibition
    19282453
    SM0146
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid* 2-Deoxy
    Altritol nucleic acid
    1,2,3,18,19,20 * 21
    1,2
    Sugar
    Sugar
    61.8 percent target mRNA inhibition
    19282453
    SM0147
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid* 2-Deoxy
    Altritol nucleic acid
    5,8,11,14 * 21
    1,2
    Sugar
    Sugar
    40 percent target mRNA inhibition
    19282453
    SM0148
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid* 2-Deoxy
    Altritol nucleic acid
    5,8,11,14,19,20 * 21
    1,2
    Sugar
    Sugar
    55.4 percent target mRNA inhibition
    19282453
    SM0149
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethoxymethyl* 2-Deoxy
    Altritol nucleic acid
    19,20 * 21
    1,2
    Sugar
    Sugar
    61.1 percent target mRNA inhibition
    19282453
    SM0150
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethoxymethyl* 2-Deoxy
    Altritol nucleic acid
    3,5,9,19,20 * 21
    1,2
    Sugar
    Sugar
    43.2 percent target mRNA inhibition
    19282453
    SM0151
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGC
    2-Aminopropoxymethyl* 2-Deoxy
    Altritol nucleic acid
    19,20 * 21
    1,2
    Sugar
    Sugar
    63.5 percent target mRNA inhibition
    19282453
    SM0152
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGC
    2-Aminopropoxymethyl* 2-Deoxy
    Altritol nucleic acid
    3,5,9,19,20 * 21
    1,2
    Sugar
    Sugar
    22.4 percent target mRNA inhibition
    19282453
    SM0153
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    Oxetane-Locked nucleic acid
    Altritol nucleic acid
    16,18
    1,2
    Sugar
    Sugar
    62.6 percent target mRNA inhibition
    19282453
    SM0154
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    Oxetane-Locked nucleic acid
    Altritol nucleic acid
    2,4
    1,2
    Sugar
    Sugar
    49.6 percent target mRNA inhibition
    19282453
    SM0155
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Fluoro* 2-O-Methyl
    Altritol nucleic acid
    1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20
    1,2
    Sugar
    Sugar
    52.7 percent target mRNA inhibition
    19282453
    SM0156
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    Altritol nucleic acid
    20
    1,2
    Sugar
    Sugar
    60.2 percent target mRNA inhibition
    19282453
    SM0157
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    Altritol nucleic acid
    19
    1,2
    Sugar
    Sugar
    56.3 percent target mRNA inhibition
    19282453
    SM0158
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    Altritol nucleic acid
    5,19,20
    1,2
    Sugar
    Sugar
    39.4 percent target mRNA inhibition
    19282453
    SM0159
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    Altritol nucleic acid
    3,9,15,20,21
    1,2
    Sugar
    Sugar
    8.4 percent target mRNA inhibition
    19282453
    SM0160
    GACGUAAACGGCCACAAGTTC
    ACUUGUGGCCGUUUACGUCGC
    4-C-Hydroxymethyl Deoxyribonucleic acid
    Altritol nucleic acid
    19,20
    1,2
    Sugar
    Sugar
    47.4 percent target mRNA inhibition
    19282453
    SM0161
    GACGTAAACGGCCACAAGTTC
    ACUUGUGGCCGUUUACGUCGC
    4-C-Hydroxymethyl Deoxyribonucleic acid
    Altritol nucleic acid
    5,19,20
    1,2
    Sugar
    Sugar
    57.5 percent target mRNA inhibition
    19282453