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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
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  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 1 * 1 * 1,3,4,9,10,11,13,14,16 * 2,5,6,7,8,12,15 * 17,18 are 8
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM5102
    ACAACAGACUUUAAUGUAAUU
    CAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,4,9,10,11,13,14,16 * 2,5,6,7,8,12,15 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    65.06 percent target mRNA inhibition
    22253019
    SM5103
    ACAACAGACUUUAAUGUAAUU
    CAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,4,9,10,11,13,14,16 * 2,5,6,7,8,12,15 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    32.43 percent target mRNA inhibition
    22253019
    SM5105
    ACAACAGACUUUAAUGUAAUU
    CAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Hydroxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,4,9,10,11,13,14,16 * 2,5,6,7,8,12,15 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    70.54 percent target mRNA inhibition
    22253019
    SM5106
    ACAACAGACUUUAAUGUAAUU
    CATTAAAGTCTGTTGTUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,4,9,10,11,13,14,16 * 2,5,6,7,8,12,15 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    31.5 percent target mRNA inhibition
    22253019
    SM5282
    ACAACAGACUUUAAUGUAAUU
    CAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Hydroxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,4,9,10,11,13,14,16 * 2,5,6,7,8,12,15 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    67.46 percent target mRNA inhibition
    22253019
    SM5283
    ACAACAGACUUUAAUGUAAUU
    CAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Fluoro* 2-Deoxy* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,4,9,10,11,13,14,16 * 2,5,6,7,8,12,15 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    50.27 percent target mRNA inhibition
    22253019
    SM5285
    ACAACAGACUUUAAUGUAAUU
    CAUUAAAGUCUGUUGUUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Hydroxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,4,9,10,11,13,14,16 * 2,5,6,7,8,12,15 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    73.27 percent target mRNA inhibition
    22253019
    SM5286
    ACAACAGACUUUAAUGUAAUU
    CATTAAAGTCTGTTGTUU
    Inverted abasic* 2-Deoxy* 2-Methoxy
    5-phosphate ribose* Inverted abasic* 2-Deoxy* 2-Fluoro* 2-Methoxy
    1,21 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19 * 20,21
    1 * 1 * 1,3,4,9,10,11,13,14,16 * 2,5,6,7,8,12,15 * 17,18
    Base; Sugar; Sugar
    Phosphate; Base; Sugar; Sugar; Sugar
    67.94 percent target mRNA inhibition
    22253019