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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 1 * 21 are 45
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM0047
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-O-Methyl* 2-Aminoethyl
    18
    1 * 21
    Sugar
    Sugar
    85.3 percent target mRNA inhibition
    19282453
    SM0048
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Guanidinoethyl
    2-O-Methyl* 2-Aminoethyl
    18
    1 * 21
    Sugar
    Sugar
    82 percent target mRNA inhibition
    19282453
    SM0049
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    2-O-Methyl* 2-Aminoethyl
    2,8,14,17
    1 * 21
    Sugar
    Sugar
    70 percent target mRNA inhibition
    19282453
    SM0050
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    2-O-Methyl* 2-Aminoethyl
    5,8,14,17,22
    1 * 21
    Sugar
    Sugar
    22 percent target mRNA inhibition
    19282453
    SM0051
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Altritol nucleic acid* 2-Deoxy
    2-O-Methyl* 2-Aminoethyl
    1,2 * 22
    1 * 21
    Sugar
    Sugar
    82 percent target mRNA inhibition
    19282453
    SM0052
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Altritol nucleic acid* 2-Deoxy
    2-O-Methyl* 2-Aminoethyl
    18,19 * 22
    1 * 21
    Sugar
    Sugar
    74 percent target mRNA inhibition
    19282453
    SM0053
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Altritol nucleic acid* 2-Deoxy
    2-O-Methyl* 2-Aminoethyl
    5,8,11,14,17 * 22
    1 * 21
    Sugar
    Sugar
    15 percent target mRNA inhibition
    19282453
    SM0054
    GACGUAAACGGCCACAAGUUCU
    ACUUGUGGCCGUUUACGUCGCU
    Altritol nucleic acid
    2-O-Methyl* 2-Aminoethyl
    20,21
    1 * 21
    Sugar
    Sugar
    75 percent target mRNA inhibition
    19282453
    SM0055
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    2-O-Methyl* 2-Aminoethyl
    19,20
    1 * 21
    Sugar
    Sugar
    72 percent target mRNA inhibition
    19282453
    SM0056
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid* 2-Deoxy
    2-O-Methyl* 2-Aminoethyl
    1,2,3,18,19,20 * 21
    1 * 21
    Sugar
    Sugar
    84 percent target mRNA inhibition
    19282453
    SM0057
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid* 2-Deoxy
    2-O-Methyl* 2-Aminoethyl
    5,8,11,14 * 21
    1 * 21
    Sugar
    Sugar
    42 percent target mRNA inhibition
    19282453
    SM0058
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid* 2-Deoxy
    2-O-Methyl* 2-Aminoethyl
    5,8,11,14,19,20 * 21
    1 * 21
    Sugar
    Sugar
    75 percent target mRNA inhibition
    19282453
    SM0059
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethoxymethyl* 2-Deoxy
    2-O-Methyl* 2-Aminoethyl
    19,20 * 21
    1 * 21
    Sugar
    Sugar
    85 percent target mRNA inhibition
    19282453
    SM0060
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethoxymethyl* 2-Deoxy
    2-O-Methyl* 2-Aminoethyl
    3,5,9,19,20 * 21
    1 * 21
    Sugar
    Sugar
    76 percent target mRNA inhibition
    19282453
    SM0061
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminopropoxymethyl* 2-Deoxy
    2-O-Methyl* 2-Aminoethyl
    19,20 * 21
    1 * 21
    Sugar
    Sugar
    84 percent target mRNA inhibition
    19282453
    SM0062
    GACGUAAACGGCCACAAGUUT
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminopropoxymethyl* 2-Deoxy
    2-O-Methyl* 2-Aminoethyl
    3,5,9,19,20 * 21
    1 * 21
    Sugar
    Sugar
    77 percent target mRNA inhibition
    19282453
    SM0063
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Oxetane-Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    16,18
    1 * 21
    Sugar
    Sugar
    90 percent target mRNA inhibition
    19282453
    SM0064
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Oxetane-Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    2,4
    1 * 21
    Sugar
    Sugar
    75 percent target mRNA inhibition
    19282453
    SM0065
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Fluoro* 2-O-Methyl
    2-O-Methyl* 2-Aminoethyl
    1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20
    1 * 21
    Sugar
    Sugar
    83 percent target mRNA inhibition
    19282453
    SM0066
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-O-Methyl* 2-Aminoethyl
    20
    1 * 21
    Sugar
    Sugar
    83 percent target mRNA inhibition
    19282453
    SM0067
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-O-Methyl* 2-Aminoethyl
    19
    1 * 21
    Sugar
    Sugar
    75 percent target mRNA inhibition
    19282453
    SM0068
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-O-Methyl* 2-Aminoethyl
    5,19,20
    1 * 21
    Sugar
    Sugar
    71 percent target mRNA inhibition
    19282453
    SM0069
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    3,9,15,20,21
    1 * 21
    Sugar
    Sugar
    72 percent target mRNA inhibition
    19282453
    SM0070
    GACGUAAACGGCCACAAGTTC
    ACUUGUGGCCGUUUACGUCGCU
    4-C-Hydroxymethyl Deoxyribonucleic acid
    2-O-Methyl* 2-Aminoethyl
    19,20
    1 * 21
    Sugar
    Sugar
    81 percent target mRNA inhibition
    19282453
    SM0071
    GACGTAAACGGCCACAAGTTC
    ACUUGUGGCCGUUUACGUCGCU
    4-C-Hydroxymethyl Deoxyribonucleic acid
    2-O-Methyl* 2-Aminoethyl
    5,19,20
    1 * 21
    Sugar
    Sugar
    88 percent target mRNA inhibition
    19282453