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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 1 * 21 are 45
    Results from 25 - 50
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM0072
    GACGUAAACG + GCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    3,9,13,15,20,21
    1 * 21
    Sugar
    Sugar
    60 percent target mRNA inhibition
    19282453
    SM0073
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGCU
    2-Deoxy* Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,22 * 20,21
    1 * 21
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0074
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGCU
    2-Deoxy* Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    1,2,4,5,7,8,10,11,13,14,16,17,19,22 * 3,6,9,12,15,18,20,21
    1 * 21
    Sugar
    Sugar
    1 percent target mRNA inhibition
    19282453
    SM0075
    GACGTAAACGGCCACAAGTTCT
    ACUUGUGGCCGUUUACGUCGCU
    2-Deoxy* Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    1,3,5,7,8,9,11,13,15,17,19,22 * 2,4,6,10,12,14,16,18,20,21
    1 * 21
    Sugar
    Sugar
    1 percent target mRNA inhibition
    19282453
    SM0076
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    5,20,21
    1 * 21
    Sugar
    Sugar
    56 percent target mRNA inhibition
    19282453
    SM0077
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    3,5,7,9,20,21
    1 * 21
    Sugar
    Sugar
    53 percent target mRNA inhibition
    19282453
    SM0078
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    3,9,13,15,20,21
    1 * 21
    Sugar
    Sugar
    75 percent target mRNA inhibition
    19282453
    SM0079
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    4-C-Hydroxymethyl Deoxyribonucleic acid
    2-O-Methyl* 2-Aminoethyl
    20,21
    1 * 21
    Sugar
    Sugar
    88 percent target mRNA inhibition
    19282453
    SM0080
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    4-C-Hydroxymethyl Deoxyribonucleic acid
    2-O-Methyl* 2-Aminoethyl
    3,5,9,13,20,21
    1 * 21
    Sugar
    Sugar
    71.8 percent target mRNA inhibition
    19282453
    SM0081
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Alfa-L-Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    20,21
    1 * 21
    Sugar
    Sugar
    80.4 percent target mRNA inhibition
    19282453
    SM0082
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Alfa-L-Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    3,9,15,20,21
    1 * 21
    Sugar
    Sugar
    85.4 percent target mRNA inhibition
    19282453
    SM0083
    GACGUAAACGGCCACAAGUUTU
    ACUUGUGGCCGUUUACGUCGCU
    4-C-Hydroxymethyl Deoxyribonucleic acid
    2-O-Methyl* 2-Aminoethyl
    21
    1 * 21
    Sugar
    Sugar
    84.6 percent target mRNA inhibition
    19282453
    SM0084
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    5,20 * 21
    1 * 21
    Sugar
    Sugar
    64.9 percent target mRNA inhibition
    19282453
    SM0085
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    UnLocked nucleic acid* Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    5 * 20,21
    1 * 21
    Sugar
    Sugar
    9.6 percent target mRNA inhibition
    19282453
    SM0086
    GACGUAAACCGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    UnLocked nucleic acid* Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    10 * 21,22
    1 * 21
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0087
    GACGUAAACGGCCACAAGUUUU
    ACUUGUGGCCGUUUACGUCGCU
    UnLocked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    21
    1 * 21
    Sugar
    Sugar
    87.9 percent target mRNA inhibition
    19282453
    SM0088
    GACGUAAACGGCCACAAGUUUU
    ACUUGUGGCCGUUUACGUCGCU
    UnLocked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    5,21
    1 * 21
    Sugar
    Sugar
    55.7 percent target mRNA inhibition
    19282453
    SM0089
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    3,8,13,15,20,21
    1 * 21
    Sugar
    Sugar
    81 percent target mRNA inhibition
    19282453
    SM0090
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    20,21
    1 * 21
    Sugar
    Sugar
    82.3 percent target mRNA inhibition
    19282453
    SM0091
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    0
    2-O-Methyl* 2-Aminoethyl
    0
    1 * 21
    0
    Sugar
    80.3 percent target mRNA inhibition
    19282453