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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for Locked nucleic acid are 409
Results from 225 - 250

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM1441	GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 0	20,21 0	Sugar 0	87.4 percent target mRNA inhibition	19282453
SM1465	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCTTU	Locked nucleic acid 4-C-Hydroxymethyl Deoxyribonucleic acid	3,9,15,20,21 20,21	Sugar Sugar	57.9 percent target mRNA inhibition	19282453
SM1468	GACGUAAACG + GCCACAAGUTC ACUUGUGGCCGUUUACGUCTTU	Locked nucleic acid 4-C-Hydroxymethyl Deoxyribonucleic acid	3,9,13,15,20,21 20,21	Sugar Sugar	52.5 percent target mRNA inhibition	19282453
SM1472	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCTTU	Locked nucleic acid 4-C-Hydroxymethyl Deoxyribonucleic acid	5,20,21 20,21	Sugar Sugar	65.8 percent target mRNA inhibition	19282453
SM1473	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCTTU	Locked nucleic acid 4-C-Hydroxymethyl Deoxyribonucleic acid	3,5,7,9,20,21 20,21	Sugar Sugar	33.2 percent target mRNA inhibition	19282453
SM1474	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCTTU	Locked nucleic acid 4-C-Hydroxymethyl Deoxyribonucleic acid	3,9,13,15,20,21 20,21	Sugar Sugar	48.5 percent target mRNA inhibition	19282453
SM1485	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCTTU	Locked nucleic acid 4-C-Hydroxymethyl Deoxyribonucleic acid	3,8,13,15,20,21 20,21	Sugar Sugar	60.3 percent target mRNA inhibition	19282453
SM1486	GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCTTU	Locked nucleic acid 4-C-Hydroxymethyl Deoxyribonucleic acid	20,21 20,21	Sugar Sugar	72.2 percent target mRNA inhibition	19282453
SM1510	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGTU	Locked nucleic acid 4-C-Hydroxymethyl Deoxyribonucleic acid	3,9,15,20,21 21	Sugar Sugar	76.7 percent target mRNA inhibition	19282453
SM1513	GACGUAAACG + GCCACAAGUTC ACUUGUGGCCGUUUACGUCGTU	Locked nucleic acid 4-C-Hydroxymethyl Deoxyribonucleic acid	3,9,13,15,20,21 21	Sugar Sugar	73.5 percent target mRNA inhibition	19282453
SM1517	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGTU	Locked nucleic acid 4-C-Hydroxymethyl Deoxyribonucleic acid	5,20,21 21	Sugar Sugar	77.2 percent target mRNA inhibition	19282453
SM1518	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGTU	Locked nucleic acid 4-C-Hydroxymethyl Deoxyribonucleic acid	3,5,7,9,20,21 21	Sugar Sugar	51.1 percent target mRNA inhibition	19282453
SM1519	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGTU	Locked nucleic acid 4-C-Hydroxymethyl Deoxyribonucleic acid	3,9,13,15,20,21 21	Sugar Sugar	60.9 percent target mRNA inhibition	19282453
SM1530	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGTU	Locked nucleic acid 4-C-Hydroxymethyl Deoxyribonucleic acid	3,8,13,15,20,21 21	Sugar Sugar	67.3 percent target mRNA inhibition	19282453
SM1531	GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCGTU	Locked nucleic acid 4-C-Hydroxymethyl Deoxyribonucleic acid	20,21 21	Sugar Sugar	78.1 percent target mRNA inhibition	19282453
SM1555	GACGUAAACGGCCACAAGUTCU ACUUGTGGCCGUUUACGUCGCU	Locked nucleic acid 2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid	3,9,15,20,21 6 * 20,21	Sugar Sugar	40.5 percent target mRNA inhibition	19282453
SM1558	GACGUAAACG + GCCACAAGUTC ACUUGTGGCCGUUUACGUCGCU	Locked nucleic acid 2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid	3,9,13,15,20,21 6 * 20,21	Sugar Sugar	22.1 percent target mRNA inhibition	19282453
SM1562	GACGTAAACGGCCACAAGUTCU ACUUGTGGCCGUUUACGUCGCU	Locked nucleic acid 2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid	5,20,21 6 * 20,21	Sugar Sugar	45 percent target mRNA inhibition	19282453
SM1563	GACGTAAACGGCCACAAGUTCU ACUUGTGGCCGUUUACGUCGCU	Locked nucleic acid 2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid	3,5,7,9,20,21 6 * 20,21	Sugar Sugar	2.7 percent target mRNA inhibition	19282453
SM1564	GACGUAAACGGCCACAAGUTCU ACUUGTGGCCGUUUACGUCGCU	Locked nucleic acid 2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid	3,9,13,15,20,21 6 * 20,21	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM1575	GACGUAAACGGCCACAAGUTCU ACUUGTGGCCGUUUACGUCGCU	Locked nucleic acid 2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid	3,8,13,15,20,21 6 * 20,21	Sugar Sugar	10.1 percent target mRNA inhibition	19282453
SM1576	GACGUAAACGGCCACAAGUTC ACUUGTGGCCGUUUACGUCGCU	Locked nucleic acid 2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid	20,21 6 * 20,21	Sugar Sugar	51.9 percent target mRNA inhibition	19282453
SM1600	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid Locked nucleic acid	3,9,15,20,21 19,20	Sugar Sugar	86.4 percent target mRNA inhibition	19282453
SM1603	GACGUAAACG + GCCACAAGUTC ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid Locked nucleic acid	3,9,13,15,20,21 19,20	Sugar Sugar	81.6 percent target mRNA inhibition	19282453
SM1607	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid Locked nucleic acid	5,20,21 19,20	Sugar Sugar	83.7 percent target mRNA inhibition	19282453



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