SMDBid | siRNA (sense/antisense) 5'>3' | Modification (sense/antisense) | Position (sense/antisense) |
Modified component (sense/antisense) |
Efficacy (%) | Reference |
SM1924 |
GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU |
Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid |
3,9,13,15,20,21 18 * 20,21 |
Sugar Sugar |
65.9 percent target mRNA inhibition | 19282453 |
SM1935 |
GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU |
Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid |
3,8,13,15,20,21 18 * 20,21 |
Sugar Sugar |
79.2 percent target mRNA inhibition | 19282453 |
SM1936 |
GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCGCU |
Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid |
20,21 18 * 20,21 |
Sugar Sugar |
89.5 percent target mRNA inhibition | 19282453 |
SM1960 |
GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU |
Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid |
3,9,15,20,21 12 * 20,21 |
Sugar Sugar |
87 percent target mRNA inhibition | 19282453 |
SM1963 |
GACGUAAACG + GCCACAAGUTC ACUUGUGGCCGUUUACGUCGCU |
Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid |
3,9,13,15,20,21 12 * 20,21 |
Sugar Sugar |
82.9 percent target mRNA inhibition | 19282453 |
SM1967 |
GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU |
Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid |
5,20,21 12 * 20,21 |
Sugar Sugar |
86.9 percent target mRNA inhibition | 19282453 |
SM1968 |
GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU |
Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid |
3,5,7,9,20,21 12 * 20,21 |
Sugar Sugar |
85.4 percent target mRNA inhibition | 19282453 |
SM1969 |
GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU |
Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid |
3,9,13,15,20,21 12 * 20,21 |
Sugar Sugar |
79.7 percent target mRNA inhibition | 19282453 |
SM1980 |
GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU |
Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid |
3,8,13,15,20,21 12 * 20,21 |
Sugar Sugar |
84.9 percent target mRNA inhibition | 19282453 |
SM1981 |
GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCGCU |
Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid |
20,21 12 * 20,21 |
Sugar Sugar |
87.1 percent target mRNA inhibition | 19282453 |
SM2005 |
GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU |
Locked nucleic acid Unlocked nucleic acid |
3,9,15,20,21 21 |
Sugar Sugar |
76.3 percent target mRNA inhibition | 19282453 |
SM2008 |
GACGUAAACG + GCCACAAGUTC ACUUGUGGCCGUUUACGUCGCU |
Locked nucleic acid Unlocked nucleic acid |
3,9,13,15,20,21 21 |
Sugar Sugar |
71.6 percent target mRNA inhibition | 19282453 |
SM2012 |
GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU |
Locked nucleic acid Unlocked nucleic acid |
5,20,21 21 |
Sugar Sugar |
73.4 percent target mRNA inhibition | 19282453 |
SM2013 |
GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU |
Locked nucleic acid Unlocked nucleic acid |
3,5,7,9,20,21 21 |
Sugar Sugar |
56.3 percent target mRNA inhibition | 19282453 |
SM2014 |
GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU |
Locked nucleic acid Unlocked nucleic acid |
3,9,13,15,20,21 21 |
Sugar Sugar |
66.2 percent target mRNA inhibition | 19282453 |
SM2025 |
GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU |
Locked nucleic acid Unlocked nucleic acid |
3,8,13,15,20,21 21 |
Sugar Sugar |
71.7 percent target mRNA inhibition | 19282453 |
SM2026 |
GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCGCU |
Locked nucleic acid Unlocked nucleic acid |
20,21 21 |
Sugar Sugar |
78.1 percent target mRNA inhibition | 19282453 |
SM2050 |
GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU |
Locked nucleic acid Unlocked nucleic acid |
3,9,15,20,21 3,21 |
Sugar Sugar |
24.1 percent target mRNA inhibition | 19282453 |
SM2053 |
GACGUAAACG + GCCACAAGUTC ACUUGUGGCCGUUUACGUCGCU |
Locked nucleic acid Unlocked nucleic acid |
3,9,13,15,20,21 3,21 |
Sugar Sugar |
52.7 percent target mRNA inhibition | 19282453 |
SM2057 |
GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU |
Locked nucleic acid Unlocked nucleic acid |
5,20,21 3,21 |
Sugar Sugar |
40 percent target mRNA inhibition | 19282453 |
SM2058 |
GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU |
Locked nucleic acid Unlocked nucleic acid |
3,5,7,9,20,21 3,21 |
Sugar Sugar |
13 percent target mRNA inhibition | 19282453 |
SM2059 |
GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU |
Locked nucleic acid Unlocked nucleic acid |
3,9,13,15,20,21 3,21 |
Sugar Sugar |
0.1 percent target mRNA inhibition | 19282453 |
SM2070 |
GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU |
Locked nucleic acid Unlocked nucleic acid |
3,8,13,15,20,21 3,21 |
Sugar Sugar |
8.5 percent target mRNA inhibition | 19282453 |
SM2071 |
GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCGCU |
Locked nucleic acid Unlocked nucleic acid |
20,21 3,21 |
Sugar Sugar |
49.3 percent target mRNA inhibition | 19282453 |
SM2095 |
GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU |
Locked nucleic acid Locked nucleic acid |
3,9,15,20,21 20,21 |
Sugar Sugar |
68.4 percent target mRNA inhibition | 19282453 |