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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for Locked nucleic acid are 409
Results from 125 - 150

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM0809	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	3,8,13,15,20,21 3,18	Sugar Sugar	0.9 percent target mRNA inhibition	19282453
SM0810	GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	20,21 3,18	Sugar Sugar	82.5 percent target mRNA inhibition	19282453
SM0834	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	3,9,15,20,21 4,18	Sugar Sugar	15.8 percent target mRNA inhibition	19282453
SM0837	GACGUAAACG + GCCACAAGUTC ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	3,9,13,15,20,21 4,18	Sugar Sugar	74.3 percent target mRNA inhibition	19282453
SM0841	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	5,20,21 4,18	Sugar Sugar	25.2 percent target mRNA inhibition	19282453
SM0842	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	3,5,7,9,20,21 4,18	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0843	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	3,9,13,15,20,21 4,18	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0854	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	3,8,13,15,20,21 4,18	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0855	GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	20,21 4,18	Sugar Sugar	79.9 percent target mRNA inhibition	19282453
SM0879	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	3,9,15,20,21 3,4,18	Sugar Sugar	85.1 percent target mRNA inhibition	19282453
SM0882	GACGUAAACG + GCCACAAGUTC ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	3,9,13,15,20,21 3,4,18	Sugar Sugar	87.8 percent target mRNA inhibition	19282453
SM0886	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	5,20,21 3,4,18	Sugar Sugar	87.1 percent target mRNA inhibition	19282453
SM0887	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	3,5,7,9,20,21 3,4,18	Sugar Sugar	19.5 percent target mRNA inhibition	19282453
SM0888	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	3,9,13,15,20,21 3,4,18	Sugar Sugar	57.9 percent target mRNA inhibition	19282453
SM0899	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	3,8,13,15,20,21 3,4,18	Sugar Sugar	69 percent target mRNA inhibition	19282453
SM0900	GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	20,21 3,4,18	Sugar Sugar	88.4 percent target mRNA inhibition	19282453
SM0924	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	3,9,15,20,21 3,18	Sugar Sugar	59.8 percent target mRNA inhibition	19282453
SM0927	GACGUAAACG + GCCACAAGUTC ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	3,9,13,15,20,21 3,18	Sugar Sugar	80.3 percent target mRNA inhibition	19282453
SM0931	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	5,20,21 3,18	Sugar Sugar	66.6 percent target mRNA inhibition	19282453
SM0932	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	3,5,7,9,20,21 3,18	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0933	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	3,9,13,15,20,21 3,18	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0944	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	3,8,13,15,20,21 3,18	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0945	GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	20,21 3,18	Sugar Sugar	77.7 percent target mRNA inhibition	19282453
SM0969	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	3,9,15,20,21 4,18	Sugar Sugar	15.7 percent target mRNA inhibition	19282453
SM0972	GACGUAAACG + GCCACAAGUTC ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	3,9,13,15,20,21 4,18	Sugar Sugar	78 percent target mRNA inhibition	19282453



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