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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for Locked nucleic acid are 409
    Results from 200 - 225
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM1292
    GACGTAAACGGCCACAAGUTCU
    ACTUGTGGCCGUUTACGTCGCU
    Locked nucleic acid
    Locked nucleic acid
    5,20,21
    3,6,14,18,20,21
    Sugar
    Sugar
    53.5 percent target mRNA inhibition
    19282453
    SM1293
    GACGTAAACGGCCACAAGUTCU
    ACTUGTGGCCGUUTACGTCGCU
    Locked nucleic acid
    Locked nucleic acid
    3,5,7,9,20,21
    3,6,14,18,20,21
    Sugar
    Sugar
    11 percent target mRNA inhibition
    19282453
    SM1294
    GACGUAAACGGCCACAAGUTCU
    ACTUGTGGCCGUUTACGTCGCU
    Locked nucleic acid
    Locked nucleic acid
    3,9,13,15,20,21
    3,6,14,18,20,21
    Sugar
    Sugar
    0.7 percent target mRNA inhibition
    19282453
    SM1305
    GACGUAAACGGCCACAAGUTCU
    ACTUGTGGCCGUUTACGTCGCU
    Locked nucleic acid
    Locked nucleic acid
    3,8,13,15,20,21
    3,6,14,18,20,21
    Sugar
    Sugar
    6.9 percent target mRNA inhibition
    19282453
    SM1306
    GACGUAAACGGCCACAAGUTC
    ACTUGTGGCCGUUTACGTCGCU
    Locked nucleic acid
    Locked nucleic acid
    20,21
    3,6,14,18,20,21
    Sugar
    Sugar
    47 percent target mRNA inhibition
    19282453
    SM1330
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    4-C-Hydroxymethyl Deoxyribonucleic acid
    3,9,15,20,21
    19,21
    Sugar
    Sugar
    81.9 percent target mRNA inhibition
    19282453
    SM1333
    GACGUAAACG + GCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    4-C-Hydroxymethyl Deoxyribonucleic acid
    3,9,13,15,20,21
    19,21
    Sugar
    Sugar
    83.4 percent target mRNA inhibition
    19282453
    SM1337
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    4-C-Hydroxymethyl Deoxyribonucleic acid
    5,20,21
    19,21
    Sugar
    Sugar
    83.8 percent target mRNA inhibition
    19282453
    SM1338
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    4-C-Hydroxymethyl Deoxyribonucleic acid
    3,5,7,9,20,21
    19,21
    Sugar
    Sugar
    49.6 percent target mRNA inhibition
    19282453
    SM1339
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    4-C-Hydroxymethyl Deoxyribonucleic acid
    3,9,13,15,20,21
    19,21
    Sugar
    Sugar
    67.4 percent target mRNA inhibition
    19282453
    SM1350
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    4-C-Hydroxymethyl Deoxyribonucleic acid
    3,8,13,15,20,21
    19,21
    Sugar
    Sugar
    69.8 percent target mRNA inhibition
    19282453
    SM1351
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    4-C-Hydroxymethyl Deoxyribonucleic acid
    20,21
    19,21
    Sugar
    Sugar
    84 percent target mRNA inhibition
    19282453
    SM1375
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    Alfa-L-Locked nucleic acid
    3,9,15,20,21
    21
    Sugar
    Sugar
    88.7 percent target mRNA inhibition
    19282453
    SM1378
    GACGUAAACG + GCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    Alfa-L-Locked nucleic acid
    3,9,13,15,20,21
    21
    Sugar
    Sugar
    88.1 percent target mRNA inhibition
    19282453
    SM1382
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    Alfa-L-Locked nucleic acid
    5,20,21
    21
    Sugar
    Sugar
    90.1 percent target mRNA inhibition
    19282453
    SM1383
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    Alfa-L-Locked nucleic acid
    3,5,7,9,20,21
    21
    Sugar
    Sugar
    83.2 percent target mRNA inhibition
    19282453
    SM1384
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    Alfa-L-Locked nucleic acid
    3,9,13,15,20,21
    21
    Sugar
    Sugar
    83.7 percent target mRNA inhibition
    19282453
    SM1395
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    Alfa-L-Locked nucleic acid
    3,8,13,15,20,21
    21
    Sugar
    Sugar
    88.5 percent target mRNA inhibition
    19282453
    SM1396
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    Alfa-L-Locked nucleic acid
    20,21
    21
    Sugar
    Sugar
    87.9 percent target mRNA inhibition
    19282453
    SM1420
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    0
    3,9,15,20,21
    0
    Sugar
    0
    88.1 percent target mRNA inhibition
    19282453
    SM1423
    GACGUAAACG + GCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    0
    3,9,13,15,20,21
    0
    Sugar
    0
    87.2 percent target mRNA inhibition
    19282453
    SM1427
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    0
    5,20,21
    0
    Sugar
    0
    87.7 percent target mRNA inhibition
    19282453
    SM1428
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    0
    3,5,7,9,20,21
    0
    Sugar
    0
    81.3 percent target mRNA inhibition
    19282453
    SM1429
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    0
    3,9,13,15,20,21
    0
    Sugar
    0
    81.2 percent target mRNA inhibition
    19282453
    SM1440
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    0
    3,8,13,15,20,21
    0
    Sugar
    0
    86.1 percent target mRNA inhibition
    19282453