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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 2-Aminoethyl are 193
    Results from 75 - 100
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM0833
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid
    5,19,20
    4,18
    Sugar
    Sugar
    14.2 percent target mRNA inhibition
    19282453
    SM0857
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid
    18
    3,4,18
    Sugar
    Sugar
    93.7 percent target mRNA inhibition
    19282453
    SM0876
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid
    20
    3,4,18
    Sugar
    Sugar
    89.1 percent target mRNA inhibition
    19282453
    SM0877
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid
    19
    3,4,18
    Sugar
    Sugar
    88.8 percent target mRNA inhibition
    19282453
    SM0878
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid
    5,19,20
    3,4,18
    Sugar
    Sugar
    79.2 percent target mRNA inhibition
    19282453
    SM0902
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    18
    3,18
    Sugar
    Sugar
    85.1 percent target mRNA inhibition
    19282453
    SM0921
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    20
    3,18
    Sugar
    Sugar
    78.9 percent target mRNA inhibition
    19282453
    SM0922
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    19
    3,18
    Sugar
    Sugar
    74.4 percent target mRNA inhibition
    19282453
    SM0923
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    5,19,20
    3,18
    Sugar
    Sugar
    20.3 percent target mRNA inhibition
    19282453
    SM0947
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    18
    4,18
    Sugar
    Sugar
    82.5 percent target mRNA inhibition
    19282453
    SM0966
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    20
    4,18
    Sugar
    Sugar
    81.2 percent target mRNA inhibition
    19282453
    SM0967
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    19
    4,18
    Sugar
    Sugar
    56 percent target mRNA inhibition
    19282453
    SM0968
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    5,19,20
    4,18
    Sugar
    Sugar
    25.8 percent target mRNA inhibition
    19282453
    SM0992
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    18
    3,4,18
    Sugar
    Sugar
    85.1 percent target mRNA inhibition
    19282453
    SM1011
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    20
    3,4,18
    Sugar
    Sugar
    77.9 percent target mRNA inhibition
    19282453
    SM1012
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    19
    3,4,18
    Sugar
    Sugar
    72.2 percent target mRNA inhibition
    19282453
    SM1013
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid
    5,19,20
    3,4,18
    Sugar
    Sugar
    62.5 percent target mRNA inhibition
    19282453
    SM1037
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-Aminoethyl
    18
    20,21
    Sugar
    Sugar
    90.7 percent target mRNA inhibition
    19282453
    SM1056
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-Aminoethyl
    20
    20,21
    Sugar
    Sugar
    89.7 percent target mRNA inhibition
    19282453
    SM1057
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-Aminoethyl
    19
    20,21
    Sugar
    Sugar
    90.7 percent target mRNA inhibition
    19282453
    SM1058
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-Aminoethyl
    5,19,20
    20,21
    Sugar
    Sugar
    89 percent target mRNA inhibition
    19282453
    SM1082
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-Aminopropyl
    18
    1
    Sugar
    Sugar
    41 percent target mRNA inhibition
    19282453
    SM1101
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-Aminopropyl
    20
    1
    Sugar
    Sugar
    62 percent target mRNA inhibition
    19282453
    SM1102
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-Aminopropyl
    19
    1
    Sugar
    Sugar
    54.7 percent target mRNA inhibition
    19282453
    SM1103
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-Aminopropyl
    5,19,20
    1
    Sugar
    Sugar
    55.2 percent target mRNA inhibition
    19282453