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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 2-Aminoethyl are 193
    Results from 125 - 150
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM1398
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    0
    18
    0
    Sugar
    0
    89.9 percent target mRNA inhibition
    19282453
    SM1417
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    0
    20
    0
    Sugar
    0
    88.8 percent target mRNA inhibition
    19282453
    SM1418
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    0
    19
    0
    Sugar
    0
    89.2 percent target mRNA inhibition
    19282453
    SM1419
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    0
    5,19,20
    0
    Sugar
    0
    87.1 percent target mRNA inhibition
    19282453
    SM1443
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCTTU
    2-Aminoethyl
    4-C-Hydroxymethyl Deoxyribonucleic acid
    18
    20,21
    Sugar
    Sugar
    56.4 percent target mRNA inhibition
    19282453
    SM1462
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCTTU
    2-Aminoethyl
    4-C-Hydroxymethyl Deoxyribonucleic acid
    20
    20,21
    Sugar
    Sugar
    65.7 percent target mRNA inhibition
    19282453
    SM1463
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCTTU
    2-Aminoethyl
    4-C-Hydroxymethyl Deoxyribonucleic acid
    19
    20,21
    Sugar
    Sugar
    60.7 percent target mRNA inhibition
    19282453
    SM1464
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCTTU
    2-Aminoethyl
    4-C-Hydroxymethyl Deoxyribonucleic acid
    5,19,20
    20,21
    Sugar
    Sugar
    51.5 percent target mRNA inhibition
    19282453
    SM1488
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGTU
    2-Aminoethyl
    4-C-Hydroxymethyl Deoxyribonucleic acid
    18
    21
    Sugar
    Sugar
    81.7 percent target mRNA inhibition
    19282453
    SM1507
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGTU
    2-Aminoethyl
    4-C-Hydroxymethyl Deoxyribonucleic acid
    20
    21
    Sugar
    Sugar
    79.3 percent target mRNA inhibition
    19282453
    SM1508
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGTU
    2-Aminoethyl
    4-C-Hydroxymethyl Deoxyribonucleic acid
    19
    21
    Sugar
    Sugar
    77.6 percent target mRNA inhibition
    19282453
    SM1509
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGTU
    2-Aminoethyl
    4-C-Hydroxymethyl Deoxyribonucleic acid
    5,19,20
    21
    Sugar
    Sugar
    69.9 percent target mRNA inhibition
    19282453
    SM1533
    GACGUAAACGGCCACAAGUUC
    ACUUGTGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    18
    6 * 20,21
    Sugar
    Sugar
    48.5 percent target mRNA inhibition
    19282453
    SM1552
    GACGUAAACGGCCACAAGUUC
    ACUUGTGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    20
    6 * 20,21
    Sugar
    Sugar
    49.4 percent target mRNA inhibition
    19282453
    SM1553
    GACGUAAACGGCCACAAGUUC
    ACUUGTGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    19
    6 * 20,21
    Sugar
    Sugar
    44.8 percent target mRNA inhibition
    19282453
    SM1554
    GACGUAAACGGCCACAAGUUC
    ACUUGTGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    5,19,20
    6 * 20,21
    Sugar
    Sugar
    33 percent target mRNA inhibition
    19282453
    SM1578
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    Locked nucleic acid
    18
    19,20
    Sugar
    Sugar
    84.8 percent target mRNA inhibition
    19282453
    SM1597
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    Locked nucleic acid
    20
    19,20
    Sugar
    Sugar
    85.8 percent target mRNA inhibition
    19282453
    SM1598
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    Locked nucleic acid
    19
    19,20
    Sugar
    Sugar
    84.5 percent target mRNA inhibition
    19282453
    SM1599
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Aminoethyl
    Locked nucleic acid
    5,19,20
    19,20
    Sugar
    Sugar
    82.2 percent target mRNA inhibition
    19282453
    SM1623
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGTCGCU
    2-Aminoethyl
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    18
    18 * 20,21
    Sugar
    Sugar
    77.7 percent target mRNA inhibition
    19282453
    SM1642
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGTCGCU
    2-Aminoethyl
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    20
    18 * 20,21
    Sugar
    Sugar
    68.4 percent target mRNA inhibition
    19282453
    SM1643
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGTCGCU
    2-Aminoethyl
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    19
    18 * 20,21
    Sugar
    Sugar
    68.8 percent target mRNA inhibition
    19282453
    SM1644
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGTCGCU
    2-Aminoethyl
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    5,19,20
    18 * 20,21
    Sugar
    Sugar
    72.5 percent target mRNA inhibition
    19282453
    SM1668
    GACGUAAACGGCCACAAGUUC
    ACUUGTGGCCGUUUACGUCGCU
    2-Aminoethyl
    2-N-Pyren-1-yl Methyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    18
    6 * 20,21
    Sugar
    Sugar
    81.1 percent target mRNA inhibition
    19282453