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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 2-Deoxy are 18
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM2163
    GCGCUGCUGGUGCCAACCCTT
    GGGUUGGCACCAGCAGCGCTT
    2-Deoxy
    2-Deoxy
    20,21
    20,21
    Sugar
    Sugar
    74 percent target mRNA inhibition
    22411910
    SM2237
    GGCCUUUCACUACUCCUACGAGCAC
    GUGCUCGUAGGAGUAGUGAAAGGCCAG
    2-Deoxy
    0
    24,25
    0
    Sugar
    0
    63 percent target mRNA inhibition
    17894530
    SM2985
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Deoxy
    0
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    0
    Sugar
    0
    38 percent target mRNA inhibition
    12923253
    SM2986
    GCAGCACGACUUCUUCAAGTT
    CUUGAAGAAGUCGUGCUGCTT
    2-Deoxy
    2-Deoxy
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19
    Sugar
    Sugar
    0 percent target mRNA inhibition
    12923253
    SM3323
    TGAGGTUUAGGAUUCGUGCUUGCACGAAUCCUAAACCUCA
    0
    2-Deoxy
    0
    1,2,3,4,5,6
    0
    Sugar
    0
    70 percent target mRNA inhibition
    19948766
    SM3324
    UGAGGUUUAGGAUUCGUGCUUGCACGAAUCCUAAACCTCA
    0
    2-Deoxy
    0
    35,36,37,38,39,40
    0
    Sugar
    0
    88 percent target mRNA inhibition
    19948766
    SM3325
    TGAGGTUUAGGAUUCGUGCUUGCACGAAUCCUAAACCTCA
    0
    2-Deoxy
    0
    1,2,3,4,5,6,35,36,37,38,39,40
    0
    Sugar
    0
    86 percent target mRNA inhibition
    19948766
    SM4720
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    2-Deoxy
    2-Deoxy
    20,21
    20,21
    Sugar
    Sugar
    95 percent target mRNA inhibition
    US 8653252 B2
    SM4721
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    2-Deoxy
    Locked nucleic acid
    20,21
    20,21
    Sugar
    Sugar
    92 percent target mRNA inhibition
    US 8653252 B2
    SM4722
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    2-Deoxy
    Locked nucleic acid
    20,21
    1,20,21
    Sugar
    Sugar
    55 percent target mRNA inhibition
    US 8653252 B2
    SM4731
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    2-Deoxy
    Locked nucleic acid
    20,21
    1,8,11,17,20,21
    Sugar
    Sugar
    15 percent target mRNA inhibition
    US 8653252 B2
    SM4732
    AUCUGAAGAAGGAGAAAAATT
    UUUUUCUCCUUCUUCAGAUTT
    2-Deoxy
    2-Deoxy
    20,21
    20,21
    Sugar
    Sugar
    95 percent target mRNA inhibition
    US 8653252 B2
    SM4733
    AUCUGAAGAAGGAGAAAAATT
    UUUUUCUCCUUCUUCAGAUTT
    2-Deoxy
    Locked nucleic acid
    20,21
    20,21
    Sugar
    Sugar
    93 percent target mRNA inhibition
    US 8653252 B2
    SM4736
    AUCUGAAGAAGGAGAAAAATT
    TUUUUCUCCUUCUUCAGAUTT
    2-Deoxy
    Locked nucleic acid
    20,21
    1,20,21
    Sugar
    Sugar
    45 percent target mRNA inhibition
    US 8653252 B2
    SM4739
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    2-Deoxy
    2-Deoxy
    20,21
    20,21
    Sugar
    Sugar
    96 percent target mRNA inhibition
    US 8653252 B2
    SM4740
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACTCAGCGUAAGTT
    2-Deoxy
    Locked nucleic acid
    20,21
    10,20,21
    Sugar
    Sugar
    52 percent target mRNA inhibition
    US 8653252 B2
    SM4741
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACTCAGCGUAAGTT
    2-Deoxy
    Locked nucleic acid
    20,21
    10,20,22
    Sugar
    Sugar
    93 percent target mRNA inhibition
    US 8653252 B2
    SM4744
    UGAGAGAAAGCACAGAAAATT
    TUUUCUGUGCUUUCUCUCATT
    2-Deoxy
    Locked nucleic acid
    20,21
    1,20,21
    Sugar
    Sugar
    34 percent target mRNA inhibition
    US 8653252 B2