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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 2-Guanidinoethyl are 48
    Results from 25 - 50
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM1128
    GACGUAAACGGCCACAAGUUC
    ACUUGTGGCCGUUUACGUCGCU
    2-Guanidinoethyl
    4-C-Hydroxymethyl Deoxyribonucleic acid* Locked nucleic acid
    18
    6 * 20,21
    Sugar
    Sugar
    88.7 percent target mRNA inhibition
    19282453
    SM1173
    GACGUAAACGGCCACAAGUUC
    ACTUGTGGCCGUUTACGTCGCU
    2-Guanidinoethyl
    4-C-Hydroxymethyl Deoxyribonucleic acid* Locked nucleic acid
    18
    3,6,14,18 * 20,21
    Sugar
    Sugar
    26.1 percent target mRNA inhibition
    19282453
    SM1219
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Guanidinoethyl
    Locked nucleic acid
    18
    20,21
    Sugar
    Sugar
    88.4 percent target mRNA inhibition
    19282453
    SM1264
    GACGUAAACGGCCACAAGUUC
    ACTUGTGGCCGUUTACGTCGCU
    2-Guanidinoethyl
    Locked nucleic acid
    18
    3,6,14,18,20,21
    Sugar
    Sugar
    63 percent target mRNA inhibition
    19282453
    SM1309
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Guanidinoethyl
    4-C-Hydroxymethyl Deoxyribonucleic acid
    18
    19,21
    Sugar
    Sugar
    84.7 percent target mRNA inhibition
    19282453
    SM1354
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Guanidinoethyl
    Alfa-L-Locked nucleic acid
    18
    21
    Sugar
    Sugar
    88.4 percent target mRNA inhibition
    19282453
    SM1399
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Guanidinoethyl
    0
    18
    0
    Sugar
    0
    88.1 percent target mRNA inhibition
    19282453
    SM1444
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCTTU
    2-Guanidinoethyl
    4-C-Hydroxymethyl Deoxyribonucleic acid
    18
    20,21
    Sugar
    Sugar
    62.9 percent target mRNA inhibition
    19282453
    SM1489
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGTU
    2-Guanidinoethyl
    4-C-Hydroxymethyl Deoxyribonucleic acid
    18
    21
    Sugar
    Sugar
    79.2 percent target mRNA inhibition
    19282453
    SM1534
    GACGUAAACGGCCACAAGUUC
    ACUUGTGGCCGUUUACGUCGCU
    2-Guanidinoethyl
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    18
    6 * 20,21
    Sugar
    Sugar
    47.1 percent target mRNA inhibition
    19282453
    SM1579
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    2-Guanidinoethyl
    Locked nucleic acid
    18
    19,20
    Sugar
    Sugar
    84.9 percent target mRNA inhibition
    19282453
    SM1624
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGTCGCU
    2-Guanidinoethyl
    2-N-Adamant-1-yl-Methylcarbonyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    18
    18 * 20,21
    Sugar
    Sugar
    72.5 percent target mRNA inhibition
    19282453
    SM1669
    GACGUAAACGGCCACAAGUUC
    ACUUGTGGCCGUUUACGUCGCU
    2-Guanidinoethyl
    2-N-Pyren-1-yl Methyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    18
    6 * 20,21
    Sugar
    Sugar
    72 percent target mRNA inhibition
    19282453
    SM1714
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGTCGCU
    2-Guanidinoethyl
    2-N-Pyren-1-yl Methyl-2-Amino-Locked nucleic acid* Locked nucleic acid
    18
    18 * 20,21
    Sugar
    Sugar
    67.3 percent target mRNA inhibition
    19282453
    SM1759
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Guanidinoethyl
    2-O-Methyl
    18
    1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22
    Sugar
    Sugar
    1.1 percent target mRNA inhibition
    19282453
    SM1804
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Guanidinoethyl
    Unlocked nucleic acid* Locked nucleic acid
    18
    6 * 20,21
    Sugar
    Sugar
    90.7 percent target mRNA inhibition
    19282453
    SM1849
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Guanidinoethyl
    Unlocked nucleic acid* Locked nucleic acid
    18
    3 * 20,21
    Sugar
    Sugar
    80.3 percent target mRNA inhibition
    19282453
    SM1894
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Guanidinoethyl
    Unlocked nucleic acid* Locked nucleic acid
    18
    18 * 20,21
    Sugar
    Sugar
    88.3 percent target mRNA inhibition
    19282453
    SM1939
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Guanidinoethyl
    Unlocked nucleic acid* Locked nucleic acid
    18
    12 * 20,21
    Sugar
    Sugar
    85.5 percent target mRNA inhibition
    19282453
    SM1984
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Guanidinoethyl
    Unlocked nucleic acid
    18
    21
    Sugar
    Sugar
    78.8 percent target mRNA inhibition
    19282453
    SM2029
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Guanidinoethyl
    Unlocked nucleic acid
    18
    3,21
    Sugar
    Sugar
    47.6 percent target mRNA inhibition
    19282453
    SM2074
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    2-Guanidinoethyl
    Locked nucleic acid
    18
    20,21
    Sugar
    Sugar
    83.2 percent target mRNA inhibition
    19282453
    SM2119
    GACGUAAACGGCCACAAGUUC
    ACTUGTGGCCGUUTACGTCGC
    2-Guanidinoethyl
    Locked nucleic acid
    18
    3,6,14,18,20,21
    Sugar
    Sugar
    10.9 percent target mRNA inhibition
    19282453