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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for 4’-thioribose* Phosphothioate are 2
Results from 0 - 25


SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM3416	GGAGAUCAACAUUUUCAAA UUUGAAAAUGUUGAUCUCC	4’-thioribose* Phosphothioate 2-O-Methyl* Phosphodiester	1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18 6,7,10,11,17,18,19 * 6,7,10,11,17,18	Sugar Sugar	IC-50 = 215.27 nM for target mRNA	US8394947, EP1765074B1
SM3417	GGAGAUCAACAUUUUCAAA UUUGAAAAUGUUGAUCUCC	4’-thioribose* Phosphothioate 2-O-Methyl* Phosphodiester	1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18 * 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18 5,8,11,14,17,18,19 * 5,8,11,14,17,18	Sugar Sugar	IC-50 = 124.53 nM for target mRNA	US8394947, EP1765074B1