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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for Altritol nucleic acid are 66
Results from 0 - 25

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM0008	GACGUAAACGGCCACAAGUUCU ACUUGUGGCCGUUUACGUCGC	Altritol nucleic acid 2-O-Methyl	20,21 2	Sugar Sugar	64.5 percent target mRNA inhibition	19282453
SM0054	GACGUAAACGGCCACAAGUUCU ACUUGUGGCCGUUUACGUCGCU	Altritol nucleic acid 2-O-Methyl* 2-Aminoethyl	20,21 1 * 21	Sugar Sugar	75 percent target mRNA inhibition	19282453
SM0099	GACGUAAACGGCCACAAGUUCU ACUUGUGGCCGUUUACGUCGCU	Altritol nucleic acid 2-O-Methyl* 2-Cyanoethyl	20,21 1 * 18	Sugar Sugar	24.7 percent target mRNA inhibition	19282453
SM0144	GACGUAAACGGCCACAAGUUCU ACUUGUGGCCGUUUACGUCGC	Altritol nucleic acid Altritol nucleic acid	20,21 1,2	Sugar Sugar	36.7 percent target mRNA inhibition	19282453
SM0189	GACGUAAACGGCCACAAGUUCU ACUUGUGGCCGUUUACGUCGCU	Altritol nucleic acid Altritol nucleic acid	20,21 20,21	Sugar Sugar	87.1 percent target mRNA inhibition	19282453
SM0234	GACGUAAACGGCCACAAGUUCU ACUUGUGGCCGUUUACGUCGCU	Altritol nucleic acid Altritol nucleic acid	20,21 5,8,11,14,17,20	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0279	GACGUAAACGGCCACAAGUUCU ACUUGUGGCCGUUUACGUCGCU	Altritol nucleic acid Altritol nucleic acid	20,21 3,6,14,18,20,21	Sugar Sugar	70.3 percent target mRNA inhibition	19282453
SM0324	GACGUAAACGGCCACAAGUUCU ACUUGUGGCCGUUUACGUCGT	Altritol nucleic acid Hexitol nucleic acid* 2-Deoxy	20,21 18,19,20 * 21	Sugar Sugar	80.3 percent target mRNA inhibition	19282453
SM0369	GACGUAAACGGCCACAAGUUCU ACUUGUGGCCGUUUACGUCGT	Altritol nucleic acid Hexitol nucleic acid* 2-Deoxy	20,21 2,18,19,20 * 21	Sugar Sugar	69.6 percent target mRNA inhibition	19282453
SM0414	GACGUAAACGGCCACAAGUUCU ACUUGUGGCCGUUUACGUCGT	Altritol nucleic acid Hexitol nucleic acid* 2-Deoxy	20,21 3,18,19,20 * 21	Sugar Sugar	75.6 percent target mRNA inhibition	19282453
SM0459	GACGUAAACGGCCACAAGUUCU ACUUGUGGCCGUUUACGUCGT	Altritol nucleic acid Hexitol nucleic acid* 2-Deoxy	20,21 2,9,18,19,20 * 21	Sugar Sugar	2.7 percent target mRNA inhibition	19282453
SM0504	GACGUAAACGGCCACAAGUUCU ACUUGUGGCCGUUUACGUCGT	Altritol nucleic acid 2-Aminoethoxymethyl* 2-Deoxy	20,21 18,19 * 21	Sugar Sugar	19.3 percent target mRNA inhibition	19282453
SM0549	GACGUAAACGGCCACAAGUUCU ACUUGUGGCCGUUUACGUCGT	Altritol nucleic acid 2-Aminopropoxymethyl* 2-Deoxy	20,21 18,19 * 21	Sugar Sugar	3.2 percent target mRNA inhibition	19282453
SM0594	GACGUAAACGGCCACAAGUUCU ACUUGUGGCCGUUUACGUCGC	Altritol nucleic acid 2-Fluoro* 2-O-Methyl	20,21 1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20	Sugar Sugar	63 percent target mRNA inhibition	19282453
SM0639	GACGUAAACGGCCACAAGUUCU ACUUGUGGCCGUUUACGUCGC	Altritol nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	20,21 3,18	Sugar Sugar	33.8 percent target mRNA inhibition	19282453
SM0684	GACGUAAACGGCCACAAGUUCU ACUUGUGGCCGUUUACGUCGC	Altritol nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	20,21 4,18	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0729	GACGUAAACGGCCACAAGUUCU ACUUGUGGCCGUUUACGUCGC	Altritol nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	20,21 3,4,18	Sugar Sugar	86.3 percent target mRNA inhibition	19282453
SM0774	GACGUAAACGGCCACAAGUUCU ACUUGUGGCCGUUUACGUCGC	Altritol nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	20,21 3,18	Sugar Sugar	72.4 percent target mRNA inhibition	19282453
SM0819	GACGUAAACGGCCACAAGUUCU ACUUGUGGCCGUUUACGUCGC	Altritol nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	20,21 4,18	Sugar Sugar	49.3 percent target mRNA inhibition	19282453
SM0864	GACGUAAACGGCCACAAGUUCU ACUUGUGGCCGUUUACGUCGC	Altritol nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	20,21 3,4,18	Sugar Sugar	86.7 percent target mRNA inhibition	19282453
SM0909	GACGUAAACGGCCACAAGUUCU ACUUGUGGCCGUUUACGUCGC	Altritol nucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	20,21 3,18	Sugar Sugar	73.5 percent target mRNA inhibition	19282453
SM0954	GACGUAAACGGCCACAAGUUCU ACUUGUGGCCGUUUACGUCGC	Altritol nucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	20,21 4,18	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0999	GACGUAAACGGCCACAAGUUCU ACUUGUGGCCGUUUACGUCGC	Altritol nucleic acid 2,4-Carbocyclic-Locked nucleic acid-Locked nucleic acid	20,21 3,4,18	Sugar Sugar	67.6 percent target mRNA inhibition	19282453
SM1044	GACGUAAACGGCCACAAGUUCU ACUUGUGGCCGUUUACGUCGCU	Altritol nucleic acid 2-Aminoethyl	20,21 20,21	Sugar Sugar	84.8 percent target mRNA inhibition	19282453
SM1089	GACGUAAACGGCCACAAGUUCU ACUUGUGGCCGUUUACGUCGCU	Altritol nucleic acid 2-Aminopropyl	20,21 1	Sugar Sugar	40.3 percent target mRNA inhibition	19282453



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