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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for Hexitol nucleic acid are 144
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM0003
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid
    2-O-Methyl
    2,8,14,17
    2
    Sugar
    Sugar
    54.2 percent target mRNA inhibition
    19282453
    SM0004
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid
    2-O-Methyl
    5,8,14,17,22
    2
    Sugar
    Sugar
    35.4 percent target mRNA inhibition
    19282453
    SM0009
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid
    2-O-Methyl
    19,20
    2
    Sugar
    Sugar
    57 percent target mRNA inhibition
    19282453
    SM0049
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    2-O-Methyl* 2-Aminoethyl
    2,8,14,17
    1 * 21
    Sugar
    Sugar
    70 percent target mRNA inhibition
    19282453
    SM0050
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    2-O-Methyl* 2-Aminoethyl
    5,8,14,17,22
    1 * 21
    Sugar
    Sugar
    22 percent target mRNA inhibition
    19282453
    SM0055
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    2-O-Methyl* 2-Aminoethyl
    19,20
    1 * 21
    Sugar
    Sugar
    72 percent target mRNA inhibition
    19282453
    SM0094
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    2-O-Methyl* 2-Cyanoethyl
    2,8,14,17
    1 * 18
    Sugar
    Sugar
    47.8 percent target mRNA inhibition
    19282453
    SM0095
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    2-O-Methyl* 2-Cyanoethyl
    5,8,14,17,22
    1 * 18
    Sugar
    Sugar
    24.8 percent target mRNA inhibition
    19282453
    SM0100
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    2-O-Methyl* 2-Cyanoethyl
    19,20
    1 * 18
    Sugar
    Sugar
    28.3 percent target mRNA inhibition
    19282453
    SM0139
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid
    Altritol nucleic acid
    2,8,14,17
    1,2
    Sugar
    Sugar
    60.1 percent target mRNA inhibition
    19282453
    SM0140
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid
    Altritol nucleic acid
    5,8,14,17,22
    1,2
    Sugar
    Sugar
    40.4 percent target mRNA inhibition
    19282453
    SM0145
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGC
    Hexitol nucleic acid
    Altritol nucleic acid
    19,20
    1,2
    Sugar
    Sugar
    44.6 percent target mRNA inhibition
    19282453
    SM0184
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    Altritol nucleic acid
    2,8,14,17
    20,21
    Sugar
    Sugar
    82.8 percent target mRNA inhibition
    19282453
    SM0185
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    Altritol nucleic acid
    5,8,14,17,22
    20,21
    Sugar
    Sugar
    59.1 percent target mRNA inhibition
    19282453
    SM0190
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    Altritol nucleic acid
    19,20
    20,21
    Sugar
    Sugar
    93.6 percent target mRNA inhibition
    19282453
    SM0229
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    Altritol nucleic acid
    2,8,14,17
    5,8,11,14,17,20
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0230
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    Altritol nucleic acid
    5,8,14,17,22
    5,8,11,14,17,20
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0235
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    Altritol nucleic acid
    19,20
    5,8,11,14,17,20
    Sugar
    Sugar
    37.7 percent target mRNA inhibition
    19282453
    SM0274
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    Altritol nucleic acid
    2,8,14,17
    3,6,14,18,20,21
    Sugar
    Sugar
    29.6 percent target mRNA inhibition
    19282453
    SM0275
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    Altritol nucleic acid
    5,8,14,17,22
    3,6,14,18,20,21
    Sugar
    Sugar
    1.4 percent target mRNA inhibition
    19282453
    SM0280
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGCU
    Hexitol nucleic acid
    Altritol nucleic acid
    19,20
    3,6,14,18,20,21
    Sugar
    Sugar
    74.9 percent target mRNA inhibition
    19282453
    SM0319
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGT
    Hexitol nucleic acid
    Hexitol nucleic acid* 2-Deoxy
    2,8,14,17
    18,19,20 * 21
    Sugar
    Sugar
    63.5 percent target mRNA inhibition
    19282453
    SM0320
    GACGUAAACGGCCACAAGUUCT
    ACUUGUGGCCGUUUACGUCGT
    Hexitol nucleic acid
    Hexitol nucleic acid* 2-Deoxy
    5,8,14,17,22
    18,19,20 * 21
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0325
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGT
    Hexitol nucleic acid
    Hexitol nucleic acid* 2-Deoxy
    19,20
    18,19,20 * 21
    Sugar
    Sugar
    80.4 percent target mRNA inhibition
    19282453
    SM0364
    GACGUAAACGGCCACAAGUUC
    ACUUGUGGCCGUUUACGUCGT
    Hexitol nucleic acid
    Hexitol nucleic acid* 2-Deoxy
    2,8,14,17
    2,18,19,20 * 21
    Sugar
    Sugar
    39.2 percent target mRNA inhibition
    19282453