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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for Locked nucleic acid are 409
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM0023
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    2-O-Methyl
    3,9,15,20,21
    2
    Sugar
    Sugar
    31 percent target mRNA inhibition
    19282453
    SM0026
    GACGUAAACG + GCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    2-O-Methyl
    3,9,13,15,20,21
    2
    Sugar
    Sugar
    73 percent target mRNA inhibition
    19282453
    SM0030
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    2-O-Methyl
    5,20,21
    2
    Sugar
    Sugar
    43.5 percent target mRNA inhibition
    19282453
    SM0031
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    2-O-Methyl
    3,5,7,9,20,21
    2
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0032
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    2-O-Methyl
    3,9,13,15,20,21
    2
    Sugar
    Sugar
    16 percent target mRNA inhibition
    19282453
    SM0043
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    2-O-Methyl
    3,8,13,15,20,21
    2
    Sugar
    Sugar
    16 percent target mRNA inhibition
    19282453
    SM0044
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    2-O-Methyl
    20,21
    2
    Sugar
    Sugar
    81 percent target mRNA inhibition
    19282453
    SM0069
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    3,9,15,20,21
    1 * 21
    Sugar
    Sugar
    72 percent target mRNA inhibition
    19282453
    SM0072
    GACGUAAACG + GCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    3,9,13,15,20,21
    1 * 21
    Sugar
    Sugar
    60 percent target mRNA inhibition
    19282453
    SM0076
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    5,20,21
    1 * 21
    Sugar
    Sugar
    56 percent target mRNA inhibition
    19282453
    SM0077
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    3,5,7,9,20,21
    1 * 21
    Sugar
    Sugar
    53 percent target mRNA inhibition
    19282453
    SM0078
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    3,9,13,15,20,21
    1 * 21
    Sugar
    Sugar
    75 percent target mRNA inhibition
    19282453
    SM0089
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    3,8,13,15,20,21
    1 * 21
    Sugar
    Sugar
    81 percent target mRNA inhibition
    19282453
    SM0090
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-O-Methyl* 2-Aminoethyl
    20,21
    1 * 21
    Sugar
    Sugar
    82.3 percent target mRNA inhibition
    19282453
    SM0114
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-O-Methyl* 2-Cyanoethyl
    3,9,15,20,21
    1 * 18
    Sugar
    Sugar
    32.9 percent target mRNA inhibition
    19282453
    SM0117
    GACGUAAACG + GCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-O-Methyl* 2-Cyanoethyl
    3,9,13,15,20,21
    1 * 18
    Sugar
    Sugar
    18.3 percent target mRNA inhibition
    19282453
    SM0121
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-O-Methyl* 2-Cyanoethyl
    5,20,21
    1 * 18
    Sugar
    Sugar
    30.3 percent target mRNA inhibition
    19282453
    SM0122
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-O-Methyl* 2-Cyanoethyl
    3,5,7,9,20,21
    1 * 18
    Sugar
    Sugar
    3.2 percent target mRNA inhibition
    19282453
    SM0123
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-O-Methyl* 2-Cyanoethyl
    3,9,13,15,20,21
    1 * 18
    Sugar
    Sugar
    0 percent target mRNA inhibition
    19282453
    SM0134
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-O-Methyl* 2-Cyanoethyl
    3,8,13,15,20,21
    1 * 18
    Sugar
    Sugar
    10.2 percent target mRNA inhibition
    19282453
    SM0135
    GACGUAAACGGCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGCU
    Locked nucleic acid
    2-O-Methyl* 2-Cyanoethyl
    20,21
    1 * 18
    Sugar
    Sugar
    57.3 percent target mRNA inhibition
    19282453
    SM0159
    GACGUAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    Altritol nucleic acid
    3,9,15,20,21
    1,2
    Sugar
    Sugar
    8.4 percent target mRNA inhibition
    19282453
    SM0162
    GACGUAAACG + GCCACAAGUTC
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    Altritol nucleic acid
    3,9,13,15,20,21
    1,2
    Sugar
    Sugar
    50.1 percent target mRNA inhibition
    19282453
    SM0166
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    Altritol nucleic acid
    5,20,21
    1,2
    Sugar
    Sugar
    36.7 percent target mRNA inhibition
    19282453
    SM0167
    GACGTAAACGGCCACAAGUTCU
    ACUUGUGGCCGUUUACGUCGC
    Locked nucleic acid
    Altritol nucleic acid
    3,5,7,9,20,21
    1,2
    Sugar
    Sugar
    2.2 percent target mRNA inhibition
    19282453