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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for Locked nucleic acid* Methylcytosine are 6
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM3048
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    Locked nucleic acid* Methylcytosine
    0
    1,20,22 * 1
    0
    Sugar; Base
    0
    97 percent target mRNA inhibition
    15653644
    SM3049
    CUUACGCUGAGUACUUCGATT
    UCGAAGUACUCAGCGUAAGTT
    Locked nucleic acid* Methylcytosine
    Locked nucleic acid
    1,20,22 * 1
    20,21
    Sugar; Base
    Sugar
    93 percent target mRNA inhibition
    15653644
    SM3050
    CTTACGCTGAGTACTTCGATT
    UCGAAGUACUCAGCGUAAGTT
    Locked nucleic acid* Methylcytosine
    0
    1,2,3,8,12,15,16,20,21 * 1
    0
    Sugar; Base
    0
    81 percent target mRNA inhibition
    15653644
    SM3051
    CTTACGCTGAGTACTTCGATT
    UCGAAGUACUCAGCGUAAGTT
    Locked nucleic acid* Methylcytosine
    Locked nucleic acid
    1,2,3,8,12,15,16,20,21 * 1
    20,21
    Sugar; Base
    0
    73 percent target mRNA inhibition
    15653644
    SM3054
    CUUACGCUGAGUACUUCGATT
    TCGAAGUACUCAGCGUAAGTT
    Locked nucleic acid* Methylcytosine
    Locked nucleic acid
    1,20,22 * 1
    1,20,21
    Sugar; Base
    Sugar
    35 percent target mRNA inhibition
    15653644
    SM3069
    CUGGUACGAUUUCGGUGAUTT
    AGCACCGAAAUCGUACCAGTT
    Locked nucleic acid* Methylcytosine
    Locked nucleic acid
    1,20,21 * 1
    20,21
    Sugar; Base
    Sugar
    93 percent target mRNA inhibition
    15653644