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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for Locked nucleic acid are 409
Results from 275 - 300

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM1780	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid 2-O-Methyl	3,9,15,20,21 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22	Sugar Sugar	5.9 percent target mRNA inhibition	19282453
SM1783	GACGUAAACG + GCCACAAGUTC ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid 2-O-Methyl	3,9,13,15,20,21 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22	Sugar Sugar	22.5 percent target mRNA inhibition	19282453
SM1787	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid 2-O-Methyl	5,20,21 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22	Sugar Sugar	16.1 percent target mRNA inhibition	19282453
SM1788	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid 2-O-Methyl	3,5,7,9,20,21 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22	Sugar Sugar	11.6 percent target mRNA inhibition	19282453
SM1789	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid 2-O-Methyl	3,9,13,15,20,21 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM1800	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid 2-O-Methyl	3,8,13,15,20,21 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22	Sugar Sugar	6.5 percent target mRNA inhibition	19282453
SM1801	GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid 2-O-Methyl	20,21 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22	Sugar Sugar	0.9 percent target mRNA inhibition	19282453
SM1825	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid	3,9,15,20,21 6 * 20,21	Sugar Sugar	89.7 percent target mRNA inhibition	19282453
SM1828	GACGUAAACG + GCCACAAGUTC ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid	3,9,13,15,20,21 6 * 20,21	Sugar Sugar	85.3 percent target mRNA inhibition	19282453
SM1832	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid	5,20,21 6 * 20,21	Sugar Sugar	90.1 percent target mRNA inhibition	19282453
SM1833	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid	3,5,7,9,20,21 6 * 20,21	Sugar Sugar	79 percent target mRNA inhibition	19282453
SM1834	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid	3,9,13,15,20,21 6 * 20,21	Sugar Sugar	87.5 percent target mRNA inhibition	19282453
SM1845	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid	3,8,13,15,20,21 6 * 20,21	Sugar Sugar	89.1 percent target mRNA inhibition	19282453
SM1846	GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid	20,21 6 * 20,21	Sugar Sugar	90.3 percent target mRNA inhibition	19282453
SM1870	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid	3,9,15,20,21 3 * 20,21	Sugar Sugar	77.1 percent target mRNA inhibition	19282453
SM1873	GACGUAAACG + GCCACAAGUTC ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid	3,9,13,15,20,21 3 * 20,21	Sugar Sugar	79.7 percent target mRNA inhibition	19282453
SM1877	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid	5,20,21 3 * 20,21	Sugar Sugar	78.3 percent target mRNA inhibition	19282453
SM1878	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid	3,5,7,9,20,21 3 * 20,21	Sugar Sugar	53.5 percent target mRNA inhibition	19282453
SM1879	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid	3,9,13,15,20,21 3 * 20,21	Sugar Sugar	62.5 percent target mRNA inhibition	19282453
SM1890	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid	3,8,13,15,20,21 3 * 20,21	Sugar Sugar	65.6 percent target mRNA inhibition	19282453
SM1891	GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid	20,21 3 * 20,21	Sugar Sugar	77.3 percent target mRNA inhibition	19282453
SM1915	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid	3,9,15,20,21 18 * 20,21	Sugar Sugar	82.9 percent target mRNA inhibition	19282453
SM1918	GACGUAAACG + GCCACAAGUTC ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid	3,9,13,15,20,21 18 * 20,21	Sugar Sugar	86.7 percent target mRNA inhibition	19282453
SM1922	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid	5,20,21 18 * 20,21	Sugar Sugar	83.9 percent target mRNA inhibition	19282453
SM1923	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid	3,5,7,9,20,21 18 * 20,21	Sugar Sugar	50.3 percent target mRNA inhibition	19282453



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