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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for Locked nucleic acid are 409
Results from 300 - 325

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM1924	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid	3,9,13,15,20,21 18 * 20,21	Sugar Sugar	65.9 percent target mRNA inhibition	19282453
SM1935	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid	3,8,13,15,20,21 18 * 20,21	Sugar Sugar	79.2 percent target mRNA inhibition	19282453
SM1936	GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid	20,21 18 * 20,21	Sugar Sugar	89.5 percent target mRNA inhibition	19282453
SM1960	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid	3,9,15,20,21 12 * 20,21	Sugar Sugar	87 percent target mRNA inhibition	19282453
SM1963	GACGUAAACG + GCCACAAGUTC ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid	3,9,13,15,20,21 12 * 20,21	Sugar Sugar	82.9 percent target mRNA inhibition	19282453
SM1967	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid	5,20,21 12 * 20,21	Sugar Sugar	86.9 percent target mRNA inhibition	19282453
SM1968	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid	3,5,7,9,20,21 12 * 20,21	Sugar Sugar	85.4 percent target mRNA inhibition	19282453
SM1969	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid	3,9,13,15,20,21 12 * 20,21	Sugar Sugar	79.7 percent target mRNA inhibition	19282453
SM1980	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid	3,8,13,15,20,21 12 * 20,21	Sugar Sugar	84.9 percent target mRNA inhibition	19282453
SM1981	GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid* Locked nucleic acid	20,21 12 * 20,21	Sugar Sugar	87.1 percent target mRNA inhibition	19282453
SM2005	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid	3,9,15,20,21 21	Sugar Sugar	76.3 percent target mRNA inhibition	19282453
SM2008	GACGUAAACG + GCCACAAGUTC ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid	3,9,13,15,20,21 21	Sugar Sugar	71.6 percent target mRNA inhibition	19282453
SM2012	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid	5,20,21 21	Sugar Sugar	73.4 percent target mRNA inhibition	19282453
SM2013	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid	3,5,7,9,20,21 21	Sugar Sugar	56.3 percent target mRNA inhibition	19282453
SM2014	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid	3,9,13,15,20,21 21	Sugar Sugar	66.2 percent target mRNA inhibition	19282453
SM2025	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid	3,8,13,15,20,21 21	Sugar Sugar	71.7 percent target mRNA inhibition	19282453
SM2026	GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid	20,21 21	Sugar Sugar	78.1 percent target mRNA inhibition	19282453
SM2050	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid	3,9,15,20,21 3,21	Sugar Sugar	24.1 percent target mRNA inhibition	19282453
SM2053	GACGUAAACG + GCCACAAGUTC ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid	3,9,13,15,20,21 3,21	Sugar Sugar	52.7 percent target mRNA inhibition	19282453
SM2057	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid	5,20,21 3,21	Sugar Sugar	40 percent target mRNA inhibition	19282453
SM2058	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid	3,5,7,9,20,21 3,21	Sugar Sugar	13 percent target mRNA inhibition	19282453
SM2059	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid	3,9,13,15,20,21 3,21	Sugar Sugar	0.1 percent target mRNA inhibition	19282453
SM2070	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid	3,8,13,15,20,21 3,21	Sugar Sugar	8.5 percent target mRNA inhibition	19282453
SM2071	GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Unlocked nucleic acid	20,21 3,21	Sugar Sugar	49.3 percent target mRNA inhibition	19282453
SM2095	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGCU	Locked nucleic acid Locked nucleic acid	3,9,15,20,21 20,21	Sugar Sugar	68.4 percent target mRNA inhibition	19282453



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