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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for Locked nucleic acid are 409
Results from 50 - 75

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM0342	GACGUAAACG + GCCACAAGUTC ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	3,9,13,15,20,21 18,19,20 * 21	Sugar Sugar	83.2 percent target mRNA inhibition	19282453
SM0346	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	5,20,21 18,19,20 * 21	Sugar Sugar	78.6 percent target mRNA inhibition	19282453
SM0347	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	3,5,7,9,20,21 18,19,20 * 21	Sugar Sugar	52.7 percent target mRNA inhibition	19282453
SM0348	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	3,9,13,15,20,21 18,19,20 * 21	Sugar Sugar	72.2 percent target mRNA inhibition	19282453
SM0359	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	3,8,13,15,20,21 18,19,20 * 21	Sugar Sugar	83.2 percent target mRNA inhibition	19282453
SM0360	GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	20,21 18,19,20 * 21	Sugar Sugar	85.1 percent target mRNA inhibition	19282453
SM0384	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	3,9,15,20,21 2,18,19,20 * 21	Sugar Sugar	75.1 percent target mRNA inhibition	19282453
SM0387	GACGUAAACG + GCCACAAGUTC ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	3,9,13,15,20,21 2,18,19,20 * 21	Sugar Sugar	70.3 percent target mRNA inhibition	19282453
SM0388	GACGUAAACG + GCCACAAGUTC ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	3,9,13,15,20,21 2,18,19,20 * 21	Sugar Sugar	70.3 percent target mRNA inhibition	19282453
SM0391	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	5,20,21 2,18,19,20 * 21	Sugar Sugar	62.8 percent target mRNA inhibition	19282453
SM0392	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	3,5,7,9,20,21 2,18,19,20 * 21	Sugar Sugar	38.5 percent target mRNA inhibition	19282453
SM0393	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	3,9,13,15,20,21 2,18,19,20 * 21	Sugar Sugar	58.7 percent target mRNA inhibition	19282453
SM0404	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	3,8,13,15,20,21 2,18,19,20 * 21	Sugar Sugar	67.6 percent target mRNA inhibition	19282453
SM0405	GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	20,21 2,18,19,20 * 21	Sugar Sugar	79.4 percent target mRNA inhibition	19282453
SM0429	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	3,9,15,20,21 3,18,19,20 * 21	Sugar Sugar	75.7 percent target mRNA inhibition	19282453
SM0432	GACGUAAACG + GCCACAAGUTC ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	3,9,13,15,20,21 3,18,19,20 * 21	Sugar Sugar	75.4 percent target mRNA inhibition	19282453
SM0436	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	5,20,21 3,18,19,20 * 21	Sugar Sugar	65.3 percent target mRNA inhibition	19282453
SM0437	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	3,5,7,9,20,21 3,18,19,20 * 21	Sugar Sugar	18.7 percent target mRNA inhibition	19282453
SM0438	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	3,9,13,15,20,21 3,18,19,20 * 21	Sugar Sugar	50.4 percent target mRNA inhibition	19282453
SM0449	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	3,8,13,15,20,21 3,18,19,20 * 21	Sugar Sugar	73.8 percent target mRNA inhibition	19282453
SM0450	GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	20,21 3,18,19,20 * 21	Sugar Sugar	80.6 percent target mRNA inhibition	19282453
SM0474	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	3,9,15,20,21 2,9,18,19,20 * 21	Sugar Sugar	18.5 percent target mRNA inhibition	19282453
SM0477	GACGUAAACG + GCCACAAGUTC ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	3,9,13,15,20,21 2,9,18,19,20 * 21	Sugar Sugar	21.1 percent target mRNA inhibition	19282453
SM0481	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	5,20,21 2,9,18,19,20 * 21	Sugar Sugar	17.4 percent target mRNA inhibition	19282453
SM0482	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	3,5,7,9,20,21 2,9,18,19,20 * 21	Sugar Sugar	0 percent target mRNA inhibition	19282453



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