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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for Locked nucleic acid are 409
Results from 75 - 100

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM0483	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	3,9,13,15,20,21 2,9,18,19,20 * 21	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0494	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	3,8,13,15,20,21 2,9,18,19,20 * 21	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0495	GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid Hexitol nucleic acid* 2-Deoxy	20,21 2,9,18,19,20 * 21	Sugar Sugar	56.7 percent target mRNA inhibition	19282453
SM0519	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid 2-Aminoethoxymethyl* 2-Deoxy	3,9,15,20,21 18,19 * 21	Sugar Sugar	24.6 percent target mRNA inhibition	19282453
SM0522	GACGUAAACG + GCCACAAGUTC ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid 2-Aminoethoxymethyl* 2-Deoxy	3,9,13,15,20,21 18,19 * 21	Sugar Sugar	35.1 percent target mRNA inhibition	19282453
SM0526	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid 2-Aminoethoxymethyl* 2-Deoxy	5,20,21 18,19 * 21	Sugar Sugar	22.4 percent target mRNA inhibition	19282453
SM0527	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid 2-Aminoethoxymethyl* 2-Deoxy	3,5,7,9,20,21 18,19 * 21	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0528	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid 2-Aminoethoxymethyl* 2-Deoxy	3,9,13,15,20,21 18,19 * 21	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0539	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid 2-Aminoethoxymethyl* 2-Deoxy	3,8,13,15,20,21 18,19 * 21	Sugar Sugar	41 percent target mRNA inhibition	19282453
SM0540	GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid 2-Aminoethoxymethyl* 2-Deoxy	20,21 18,19 * 21	Sugar Sugar	62.6 percent target mRNA inhibition	19282453
SM0564	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid 2-Aminopropoxymethyl* 2-Deoxy	3,9,15,20,21 18,19 * 21	Sugar Sugar	7.2 percent target mRNA inhibition	19282453
SM0567	GACGUAAACG + GCCACAAGUTC ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid 2-Aminopropoxymethyl* 2-Deoxy	3,9,13,15,20,21 18,19 * 21	Sugar Sugar	30.7 percent target mRNA inhibition	19282453
SM0571	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid 2-Aminopropoxymethyl* 2-Deoxy	5,20,21 18,19 * 21	Sugar Sugar	18.4 percent target mRNA inhibition	19282453
SM0572	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid 2-Aminopropoxymethyl* 2-Deoxy	3,5,7,9,20,21 18,19 * 21	Sugar Sugar	9 percent target mRNA inhibition	19282453
SM0573	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid 2-Aminopropoxymethyl* 2-Deoxy	3,9,13,15,20,21 18,19 * 21	Sugar Sugar	1.4 percent target mRNA inhibition	19282453
SM0584	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid 2-Aminopropoxymethyl* 2-Deoxy	3,8,13,15,20,21 18,19 * 21	Sugar Sugar	27.1 percent target mRNA inhibition	19282453
SM0585	GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCGT	Locked nucleic acid 2-Aminopropoxymethyl* 2-Deoxy	20,21 18,19 * 21	Sugar Sugar	49.7 percent target mRNA inhibition	19282453
SM0609	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Fluoro* 2-O-Methyl	3,9,15,20,21 1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20	Sugar Sugar	28.5 percent target mRNA inhibition	19282453
SM0612	GACGUAAACG + GCCACAAGUTC ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Fluoro* 2-O-Methyl	3,9,13,15,20,21 1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20	Sugar Sugar	77.7 percent target mRNA inhibition	19282453
SM0616	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Fluoro* 2-O-Methyl	5,20,21 1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20	Sugar Sugar	49 percent target mRNA inhibition	19282453
SM0617	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Fluoro* 2-O-Methyl	3,5,7,9,20,21 1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0618	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Fluoro* 2-O-Methyl	3,9,13,15,20,21 1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0629	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Fluoro* 2-O-Methyl	3,8,13,15,20,21 1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20	Sugar Sugar	10.5 percent target mRNA inhibition	19282453
SM0630	GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Fluoro* 2-O-Methyl	20,21 1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20	Sugar Sugar	81.2 percent target mRNA inhibition	19282453
SM0654	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	3,9,15,20,21 3,18	Sugar Sugar	22.4 percent target mRNA inhibition	19282453



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