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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for Locked nucleic acid are 409
Results from 100 - 125

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM0657	GACGUAAACG + GCCACAAGUTC ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	3,9,13,15,20,21 3,18	Sugar Sugar	63.4 percent target mRNA inhibition	19282453
SM0661	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	5,20,21 3,18	Sugar Sugar	42.4 percent target mRNA inhibition	19282453
SM0662	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	3,5,7,9,20,21 3,18	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0663	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	3,9,13,15,20,21 3,18	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0674	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	3,8,13,15,20,21 3,18	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0675	GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	20,21 3,18	Sugar Sugar	53.9 percent target mRNA inhibition	19282453
SM0699	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	3,9,15,20,21 4,18	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0702	GACGUAAACG + GCCACAAGUTC ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	3,9,13,15,20,21 4,18	Sugar Sugar	60.5 percent target mRNA inhibition	19282453
SM0706	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	5,20,21 4,18	Sugar Sugar	5.8 percent target mRNA inhibition	19282453
SM0707	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	3,5,7,9,20,21 4,18	Sugar Sugar	3.6 percent target mRNA inhibition	19282453
SM0708	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	3,9,13,15,20,21 4,18	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0719	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	3,8,13,15,20,21 4,18	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0720	GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	20,21 4,18	Sugar Sugar	64.4 percent target mRNA inhibition	19282453
SM0744	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	3,9,15,20,21 3,4,18	Sugar Sugar	78.3 percent target mRNA inhibition	19282453
SM0747	GACGUAAACG + GCCACAAGUTC ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	3,9,13,15,20,21 3,4,18	Sugar Sugar	87.8 percent target mRNA inhibition	19282453
SM0751	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	5,20,21 3,4,18	Sugar Sugar	82.4 percent target mRNA inhibition	19282453
SM0752	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	3,5,7,9,20,21 3,4,18	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0753	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	3,9,13,15,20,21 3,4,18	Sugar Sugar	0 percent target mRNA inhibition	19282453
SM0764	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	3,8,13,15,20,21 3,4,18	Sugar Sugar	63.5 percent target mRNA inhibition	19282453
SM0765	GACGUAAACGGCCACAAGUTC ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2-Deoxy-2-N,4-C-Ethylene-Locked nucleic acid	20,21 3,4,18	Sugar Sugar	89.5 percent target mRNA inhibition	19282453
SM0789	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	3,9,15,20,21 3,18	Sugar Sugar	65.1 percent target mRNA inhibition	19282453
SM0792	GACGUAAACG + GCCACAAGUTC ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	3,9,13,15,20,21 3,18	Sugar Sugar	80.4 percent target mRNA inhibition	19282453
SM0796	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	5,20,21 3,18	Sugar Sugar	72.3 percent target mRNA inhibition	19282453
SM0797	GACGTAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	3,5,7,9,20,21 3,18	Sugar Sugar	0.4 percent target mRNA inhibition	19282453
SM0798	GACGUAAACGGCCACAAGUTCU ACUUGUGGCCGUUUACGUCGC	Locked nucleic acid 2,4-Carbocyclic-Ethylene-bridged nucleic acid-Locked nucleic acid	3,9,13,15,20,21 3,18	Sugar Sugar	0 percent target mRNA inhibition	19282453



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