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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
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  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
  • Total number of Results for Triazole-linked nucleic acid* Phenyl are 7
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4383
    CUUACGCUGAGUACUUCGACU
    UCGAAGUACUCAGCGUAAGTT
    Triazole-linked nucleic acid* Phenyl
    2-Deoxythymidine
    20 * 21
    20,21
    Phosphate ; Base
    Sugar
    92 percent target mRNA inhibition
    25699137
    SM4398
    CUUACGCUGAGUACUUCGACU
    UCGAAGUACUCAGCGUAAGTT
    Triazole-linked nucleic acid* Phenyl
    2-Deoxythymidine
    20 * 21
    20,21
    Phosphate ; Base
    Sugar
    97 percent target mRNA inhibition
    25699137
    SM4405
    GUGAAGUCAACAUGCCUGCCU
    GCAGGCAUGUUGACUUCACTT
    Triazole-linked nucleic acid* Phenyl
    2-Deoxythymidine
    20 * 21
    20,21
    Phosphate ; Base
    Sugar
    75 percent target mRNA inhibition
    25699137
    SM4412
    GUGAAGUCAACAUGCCUGCCU
    GCAGGCAUGUUGACUUCACTT
    Triazole-linked nucleic acid* Phenyl
    2-Deoxythymidine
    20 * 21
    20,21
    Phosphate ; Base
    Sugar
    82 percent target mRNA inhibition
    25699137
    SM4416
    CUUACGCUGAGUACUUCGACU
    UCGAAGUACUCAGCGUAAGTT
    Triazole-linked nucleic acid* Phenyl
    2-Deoxythymidine
    20 * 21
    20,21
    Phosphate ; Base
    Sugar
    20 percent target mRNA inhibition
    25699137
    SM4420
    CUUACGCUGAGUACUUCGACU
    UCGAAGUACUCAGCGUAAGTT
    Triazole-linked nucleic acid* Phenyl
    2-Deoxythymidine
    20 * 21
    20,21
    Phosphate ; Base
    Sugar
    34 percent target mRNA inhibition
    25699137
    SM4424
    CUUACGCUGAGUACUUCGACU
    UCGAAGUACUCAGCGUAAGTT
    Triazole-linked nucleic acid* Phenyl
    2-Deoxythymidine
    20 * 21
    20,21
    Phosphate ; Base
    Sugar
    63 percent target mRNA inhibition
    25699137