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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).

• By modification in sense strand


• By modification position in sense strand


• By modification in antisense strand


• By modification position in antisense strand


• Reference
Total number of Results for UnLocked nucleic acid are 135
Results from 0 - 25

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SMDBid	siRNA (sense/antisense) 5'>3'	Modification (sense/antisense)	Position (sense/antisense)	Modified component (sense/antisense)	Efficacy (%)	Reference
SM0041	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid 2-O-Methyl	21 2	Sugar Sugar	82 percent target mRNA inhibition	19282453
SM0042	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid 2-O-Methyl	5,21 2	Sugar Sugar	56 percent target mRNA inhibition	19282453
SM0087	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid 2-O-Methyl* 2-Aminoethyl	21 1 * 21	Sugar Sugar	87.9 percent target mRNA inhibition	19282453
SM0088	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid 2-O-Methyl* 2-Aminoethyl	5,21 1 * 21	Sugar Sugar	55.7 percent target mRNA inhibition	19282453
SM0132	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid 2-O-Methyl* 2-Cyanoethyl	21 1 * 18	Sugar Sugar	47.9 percent target mRNA inhibition	19282453
SM0133	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid 2-O-Methyl* 2-Cyanoethyl	5,21 1 * 18	Sugar Sugar	21.2 percent target mRNA inhibition	19282453
SM0177	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid Altritol nucleic acid	21 1,2	Sugar Sugar	62.4 percent target mRNA inhibition	19282453
SM0178	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGC	UnLocked nucleic acid Altritol nucleic acid	5,21 1,2	Sugar Sugar	28.9 percent target mRNA inhibition	19282453
SM0222	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid Altritol nucleic acid	21 20,21	Sugar Sugar	89.2 percent target mRNA inhibition	19282453
SM0223	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid Altritol nucleic acid	5,21 20,21	Sugar Sugar	88.2 percent target mRNA inhibition	19282453
SM0267	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid Altritol nucleic acid	21 5,8,11,14,17,20	Sugar Sugar	6.2 percent target mRNA inhibition	19282453
SM0268	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid Altritol nucleic acid	5,21 5,8,11,14,17,20	Sugar Sugar	21.6 percent target mRNA inhibition	19282453
SM0312	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid Altritol nucleic acid	21 3,6,14,18,20,21	Sugar Sugar	82 percent target mRNA inhibition	19282453
SM0313	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGCU	UnLocked nucleic acid Altritol nucleic acid	5,21 3,6,14,18,20,21	Sugar Sugar	77.2 percent target mRNA inhibition	19282453
SM0357	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid Hexitol nucleic acid* 2-Deoxy	21 18,19,20 * 21	Sugar Sugar	84.5 percent target mRNA inhibition	19282453
SM0358	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid Hexitol nucleic acid* 2-Deoxy	5,21 18,19,20 * 21	Sugar Sugar	78.3 percent target mRNA inhibition	19282453
SM0402	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid Hexitol nucleic acid* 2-Deoxy	21 2,18,19,20 * 21	Sugar Sugar	85.3 percent target mRNA inhibition	19282453
SM0403	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid Hexitol nucleic acid* 2-Deoxy	5,21 2,18,19,20 * 21	Sugar Sugar	58.6 percent target mRNA inhibition	19282453
SM0447	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid Hexitol nucleic acid* 2-Deoxy	21 3,18,19,20 * 21	Sugar Sugar	87 percent target mRNA inhibition	19282453
SM0448	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid Hexitol nucleic acid* 2-Deoxy	5,21 3,18,19,20 * 21	Sugar Sugar	66.6 percent target mRNA inhibition	19282453
SM0492	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid Hexitol nucleic acid* 2-Deoxy	21 2,9,18,19,20 * 21	Sugar Sugar	45.5 percent target mRNA inhibition	19282453
SM0493	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid Hexitol nucleic acid* 2-Deoxy	5,21 2,9,18,19,20 * 21	Sugar Sugar	1.8 percent target mRNA inhibition	19282453
SM0537	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid 2-Aminoethoxymethyl* 2-Deoxy	21 18,19 * 21	Sugar Sugar	51.9 percent target mRNA inhibition	19282453
SM0538	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid 2-Aminoethoxymethyl* 2-Deoxy	5,21 18,19 * 21	Sugar Sugar	14.1 percent target mRNA inhibition	19282453
SM0582	GACGUAAACGGCCACAAGUUUU ACUUGUGGCCGUUUACGUCGT	UnLocked nucleic acid 2-Aminopropoxymethyl* 2-Deoxy	21 18,19 * 21	Sugar Sugar	28.9 percent target mRNA inhibition	19282453



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