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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 1,2,3,4 are 11
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4879
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    0
    1,2,3,4
    0
    Sugar
    0
    94.2 percent target mRNA inhibition
    17150641
    SM4884
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    4-Thioribose
    1,2,3,4
    16,17,18,19
    Sugar
    Sugar
    86.1 percent target mRNA inhibition
    17150641
    SM4887
    AAACAUGCAGAAAAUGCUGTT
    CAGCAUUUUCUGCAUGUUUTT
    4-Thioribose
    0
    1,2,3,4
    0
    Sugar
    0
    70.4 percent target mRNA inhibition
    17150641
    SM4892
    AAACAUGCAGAAAAUGCUGTT
    CAGCAUUUUCUGCAUGUUUTT
    4-Thioribose
    4-Thioribose
    1,2,3,4
    16,17,18,19
    Sugar
    Sugar
    80.7 percent target mRNA inhibition
    17150641
    SM4898
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    0
    1,2,3,4
    0
    Sugar
    0
    94.2 percent target mRNA inhibition
    17924376
    SM4917
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    4-Thioribose
    1,2,3,4
    16,17,18,19
    Sugar
    Sugar
    86.1 percent target mRNA inhibition
    17924376
    SM4929
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    4-Thioribose
    1,2,3,4
    1,2,18,19
    Sugar
    Sugar
    85.4 percent target mRNA inhibition
    17924376
    SM4934
    AAACAUGCAGAAAAUGCUGTT
    CAGCAUUUUCUGCAUGUUUTT
    4-Thioribose
    0
    1,2,3,4
    0
    Sugar
    0
    70.4 percent target mRNA inhibition
    17924376
    SM4941
    AAACAUGCAGAAAAUGCUGTT
    CAGCAUUUUCUGCAUGUUUTT
    4-Thioribose
    4-Thioribose
    1,2,3,4
    18,19
    Sugar
    Sugar
    76.5 percent target mRNA inhibition
    17924376
    SM4945
    AAACAUGCAGAAAAUGCUGTT
    CAGCAUUUUCUGCAUGUUUTT
    4-Thioribose
    4-Thioribose
    1,2,3,4
    16,17,18,19
    Sugar
    Sugar
    80.7 percent target mRNA inhibition
    17924376
    SM4949
    AAACAUGCAGAAAAUGCUGTT
    CAGCAUUUUCUGCAUGUUUTT
    4-Thioribose
    4-Thioribose
    1,2,3,4
    1,2,18,19
    Sugar
    Sugar
    60.2 percent target mRNA inhibition
    17924376