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Note: (i) 0 indicates modification in opposite strand. (ii) Multiple modifications are separated bt asterisk (*).
  • By modification in sense strand

  • By modification position in sense strand

  • By modification in antisense strand

  • By modification position in antisense strand

  • Reference
    • Total number of Results for 1,2,3,4,5,6,14,15,16,17,18,19 are 9
    Results from 0 - 25
    SMDBidsiRNA (sense/antisense) 5'>3'Modification (sense/antisense)Position (sense/antisense) Modified component (sense/antisense) Efficacy (%)Reference
    SM4868
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    0
    1,2,3,4,5,6,14,15,16,17,18,19
    0
    Sugar
    0
    91.5 percent target mRNA inhibition (IC-50 = 0.16 nM)
    15919084
    SM4900
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    0
    1,2,3,4,5,6,14,15,16,17,18,19
    0
    Sugar
    0
    91.5 percent target mRNA inhibition
    17924376
    SM4919
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    4-Thioribose
    1,2,3,4,5,6,14,15,16,17,18,19
    1,2,3,4,5,6,14,15,16,17,18,19
    Sugar
    Sugar
    0 percent target mRNA inhibition
    17924376
    SM4924
    CGUACGCGGAAUACUUCGATT
    GCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    4-Thioribose
    1,2,3,4,5,6,14,15,16,17,18,19
    18,19
    Sugar
    Sugar
    74.2 percent target mRNA inhibition
    17924376
    SM4927
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    4-Thioribose
    1,2,3,4,5,6,14,15,16,17,18,19
    16,17,18,19
    Sugar
    Sugar
    44.4 percent target mRNA inhibition
    17924376
    SM4931
    CGUACGCGGAAUACUUCGATT
    UCGAAGUAUUCCGCGUACGTT
    4-Thioribose
    4-Thioribose
    1,2,3,4,5,6,14,15,16,17,18,19
    1,2,18,19
    Sugar
    Sugar
    28.6 percent target mRNA inhibition
    17924376
    SM4936
    AAACAUGCAGAAAAUGCUGTT
    CAGCAUUUUCUGCAUGUUUTT
    4-Thioribose
    0
    1,2,3,4,5,6,14,15,16,17,18,19
    0
    Sugar
    0
    75.4 percent target mRNA inhibition
    17924376
    SM4943
    AAACAUGCAGAAAAUGCUGTT
    CAGCAUUUUCUGCAUGUUUTT
    4-Thioribose
    0
    1,2,3,4,5,6,14,15,16,17,18,19
    0
    Sugar
    0
    87 percent target mRNA inhibition
    17924376
    SM4947
    AAACAUGCAGAAAAUGCUGTT
    CAGCAUUUUCUGCAUGUUUTT
    4-Thioribose
    4-Thioribose
    1,2,3,4,5,6,14,15,16,17,18,19
    16,17,18,19
    Sugar
    Sugar
    84.4 percent target mRNA inhibition
    17924376