| Field | Sense | Antisense |
| siRNA chemical modification | Locked nucleic acid | Locked nucleic acid |
| siRNA modification types | 2 | 1 |
| Overall number of modifications | 6 | 2 |
| Position of modifications | 3,9,13,15,20,21 | 20,21 |
| Modification on sugar or base or phosphate | Sugar | Sugar |
| SMILES (Click to view structure & nomenclature) |
OCC12COC(CO1)C2O |
OCC12COC(CO1)C2O |
| siRNA Sequence | GACGUAAACG; GCCACAAGUTC | ACUUGUGGCCGUUUACGUCGC |
| siRNA length base-pair | 21 (10;11) | 21 |
| siRNA name in paper | sisiRNA | sisiRNA |
| Biological activity | NA | |
| Experiment used to check activity | NA | |
| Melting temperature (oC) | Inreased | |
| Target gene | NA | |
| siRNA concentration | 400ug/kg; 4mg/kg; 10mg/kg | |
| Cell or Organism used | Balb C mice | |
| Transfection method | Injection | |
| Duration after transfection | 0.016, 0.08, 0.25, 0.5, 24 Hours | |
| Article title | The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice |
|
| Reference | 19401674 | |