SM2369 Chemically modified siRNA information

Field Sense Antisense
siRNA chemical modification 0 2-O-Guanidinopropyl
siRNA modification types 0 1
Overall number of modifications 0 1
Position of modifications 0 21
Modification on sugar or base or phosphate 0 Sugar
SMILES
(Click to view structure & nomenclature)
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NC(=N)NCCCOC1COC(CO)C1O



siRNA Sequence ACCUUGAGGCAUACUUCAATT UUGAAGUAUGCCUCAAGGUCG
siRNA length base-pair 21 21
siRNA name in paper GP21 siRNA3 GP21 siRNA3
Biological activity 93 percent target mRNA inhibition
Experiment used to check activity Luciferase reporter assay
Melting temperature (oC) NA
Target gene HBx gene of hepatitis B virus
siRNA concentration 10 nM
Cell or Organism used Huh7 cells
Transfection method Lipofectamine 2000
Duration after transfection 48 Hours
Article title Inhibition of hepatitis B virus replication in cultured cells and in vivo using 2'-O-guanidinopropyl modified siRNAs
Reference23743442