| Field | Sense | Antisense |
| siRNA chemical modification | Locked nucleic acid | 2,4-Locked nucleic acid |
| siRNA modification types | 1 | 1 |
| Overall number of modifications | 7 | 2 |
| Position of modifications | 1,2,5,15,18,22,23 | 22,23 |
| Modification on sugar or base or phosphate | Sugar | Sugar |
| SMILES (Click to view structure & nomenclature) |
OCC12COC(CO1)C2O |
OCC12COC(CO1)C2O |
| siRNA Sequence | GTCATCACACUGAATACCAAUTT | AUUGGUAUUCAGUGUGAUGACTT |
| siRNA length base-pair | 23 | 23 |
| siRNA name in paper | Apo B-siBNA | Apo B-siBNA |
| Biological activity | High target target mRNA inhibition efficacy | |
| Experiment used to check activity | mRNA analysis | |
| Melting temperature (oC) | NA | |
| Target gene | Apolipoprotein B gene | |
| siRNA concentration | 2 μg/mL | |
| Cell or Organism used | C57BL/6J mice | |
| Transfection method | Polyethylenimine-pullulan | |
| Duration after transfection | 73 Hours (3 days) | |
| Article title | Efficient reduction of serum cholesterol by combining a liver-targeted gene delivery system with chemically modified apolipoprotein B siRNA |
|
| Reference | 22974833 | |