SM2534 Chemically modified siRNA information

Field Sense Antisense
siRNA chemical modification 2-Deoxythymidine 0
siRNA modification types 1 0
Overall number of modifications 2 0
Position of modifications 1,2 0
Modification on sugar or base or phosphate Sugar 0
SMILES
(Click to view structure & nomenclature)
CC1=CN(C2CC(O)C(CO)O2)C(=O)NC1=O



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siRNA Sequence UCUUGAUGUACUCCCCUCG CGAGGGGAGUACAUCAAGA
siRNA length base-pair 19 19
siRNA name in paper Akt1 V2 Akt1 V2
Biological activity NA
Experiment used to check activity Real-time PCR
Melting temperature (oC) NA
Target gene Akt gene
siRNA concentration 1 to 40 nM
Cell or Organism used HeLa cells
Transfection method Oligofectamine (Invitrogen)
Duration after transfection 48 Hours
Article title Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells
Reference12771196