SM2665 Chemically modified siRNA information

Field Sense Antisense
siRNA chemical modification Peptide nucleic acids Peptide nucleic acids
siRNA modification types 1 1
Overall number of modifications 1 1
Position of modifications 21 21
Modification on sugar or base or phosphate Phosphate Phosphate
SMILES
(Click to view structure & nomenclature)
CNC(=O)CN(C)C(C)=O



CNC(=O)CN(C)C(C)=O



siRNA Sequence UCGAAGUAUUCCGCGUACGTT CGUACGCGGAAUACUUCGATT
siRNA length base-pair 21 21
siRNA name in paper D D
Biological activity 75 percent target mRNA inhibition
Experiment used to check activity Dual luciferase reporter assay
Melting temperature (oC) NA
Target gene Luciferase gene
siRNA concentration 10 nM
Cell or Organism used HeLa cells
Transfection method Cationic liposomes
Duration after transfection 48 Hours
Article title RNA interference in mammalia cells by RNA-3'-PNA chimeras
Reference19325750