SM2667 Chemically modified siRNA information

Field Sense Antisense
siRNA chemical modification Peptide nucleic acids 0
siRNA modification types 1 0
Overall number of modifications 1 0
Position of modifications 21 0
Modification on sugar or base or phosphate Phosphate 0
SMILES
(Click to view structure & nomenclature)
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CNC(=O)CN(C)C(C)=O



siRNA Sequence UCGAAGUAUUCCGCGUACGTT CGUACGCGGAAUACUUCGATT
siRNA length base-pair 21 21
siRNA name in paper B B
Biological activity 80 percent target mRNA inhibition
Experiment used to check activity Dual luciferase reporter assay
Melting temperature (oC) NA
Target gene Luciferase gene
siRNA concentration 1 nM
Cell or Organism used HeLa cells
Transfection method Cationic liposomes
Duration after transfection 48 Hours
Article title RNA interference in mammalia cells by RNA-3'-PNA chimeras
Reference19325750