SM2668 Chemically modified siRNA information

Field Sense Antisense
siRNA chemical modification 0 Peptide nucleic acids
siRNA modification types 0 1
Overall number of modifications 0 1
Position of modifications 0 21
Modification on sugar or base or phosphate 0 Phosphate
SMILES
(Click to view structure & nomenclature)
-



CNC(=O)CN(C)C(C)=O



siRNA Sequence UCGAAGUAUUCCGCGUACGTT CGUACGCGGAAUACUUCGATT
siRNA length base-pair 21 21
siRNA name in paper C C
Biological activity 79 percent target mRNA inhibition
Experiment used to check activity Dual luciferase reporter assay
Melting temperature (oC) NA
Target gene Luciferase gene
siRNA concentration 1 nM
Cell or Organism used HeLa cells
Transfection method Cationic liposomes
Duration after transfection 48 Hours
Article title RNA interference in mammalia cells by RNA-3'-PNA chimeras
Reference19325750