SM3014 Chemically modified siRNA information

Field Sense Antisense
siRNA chemical modification 0 O-Methyl
siRNA modification types 0 1
Overall number of modifications 0 21
Position of modifications 0 1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,22
Modification on sugar or base or phosphate 0 Sugar
SMILES
(Click to view structure & nomenclature)
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COC1C(O)OC(CO)C1O



siRNA Sequence GACGUAAACGGCCACAAGUUCU ACUUGUGGCCGUUUACGUCGCU
siRNA length base-pair 22 22
siRNA name in paper W207 W106
Biological activity 75 percent target mRNA inhibition
Experiment used to check activity Dual luciferase reporter assay
Melting temperature (oC) NA
Target gene EGFP gene
siRNA concentration 10 nM
Cell or Organism used H1299 cells
Transfection method Lipofectamine 2000
Duration after transfection 48 Hours
Article title In vivo screening of modified siRNAs for non-specific antiviral effect in a small fish model: number and localization in the strands are important
Reference22287630