SM3112 Chemically modified siRNA information

Field Sense Antisense
siRNA chemical modification 0 2,3-Di-Chlorobenzene
siRNA modification types 0 1
Overall number of modifications 0 1
Position of modifications 0 7
Modification on sugar or base or phosphate 0 Base
SMILES
(Click to view structure & nomenclature)
-



OCC1OC(C(O)C1O)C1=C(Cl)C(Cl)=CC=C1



siRNA Sequence AUCUGAAGAAGGAGAAAAATT UUUUUCUCCUUCUUCAGAUTT
siRNA length base-pair 21 21
siRNA name in paper rL rL
Biological activity 92 percent target mRNA inhibition
Experiment used to check activity Dual luciferase reporter assay
Melting temperature (oC) 66
Target gene Luciferase gene
siRNA concentration 2.1 ng
Cell or Organism used HeLa cells
Transfection method Liposomes
Duration after transfection 22 Hours
Article title Steric effects in RNA interference: probing the influence of nucleobase size and shape
Reference18624291