SM3121 Chemically modified siRNA information

Field Sense Antisense
siRNA chemical modification 0 4-Methylbenzimidazole
siRNA modification types 0 1
Overall number of modifications 0 1
Position of modifications 0 8
Modification on sugar or base or phosphate 0 Base
SMILES
(Click to view structure & nomenclature)
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CC1=CC=CC2=C1N=CN2C1OC(CO)C(O)C1O



siRNA Sequence ACCUGACGUUGUACAAAUUTT AAUUUGUACAACGUCAGGUTT
siRNA length base-pair 21 21
siRNA name in paper 8Z 8Z
Biological activity 0 percent target mRNA inhibition
Experiment used to check activity Dual luciferase reporter assay
Melting temperature (oC) 59
Target gene Luciferase gene
siRNA concentration 2.1 ng
Cell or Organism used HeLa cells
Transfection method Liposomes
Duration after transfection 22 Hours
Article title Steric effects in RNA interference: probing the influence of nucleobase size and shape
Reference18624291