SM3126 Chemically modified siRNA information

Field Sense Antisense
siRNA chemical modification 4-Methylbenzimidazole 0
siRNA modification types 1 0
Overall number of modifications 1 0
Position of modifications 13 0
Modification on sugar or base or phosphate Base 0
SMILES
(Click to view structure & nomenclature)
CC1=CC=CC2=C1N=CN2C1OC(CO)C(O)C1O



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siRNA Sequence ACCUGACGUUGUACAAAUUTT AAUATTTGTACAACGTCAGGT
siRNA length base-pair 21 21
siRNA name in paper PS13Z PS13Z
Biological activity 75 percent target mRNA inhibition
Experiment used to check activity Dual luciferase reporter assay
Melting temperature (oC) 61
Target gene Luciferase gene
siRNA concentration 2.1 ng
Cell or Organism used HeLa cells
Transfection method Liposomes
Duration after transfection 22 Hours
Article title Steric effects in RNA interference: probing the influence of nucleobase size and shape
Reference18624291