SM3233 Chemically modified siRNA information

Field Sense Antisense
siRNA chemical modification Tricyclodeoxyribonucleic acid 0
siRNA modification types 1 0
Overall number of modifications 5 0
Position of modifications 2,5,7,20,21 0
Modification on sugar or base or phosphate Sugar 0
SMILES
(Click to view structure & nomenclature)
OC1CCC2(O)CCOC12



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siRNA Sequence GCAGCACGACUUCUUCAAGTT CUUGAAGAAGUCGUGCUGCTT
siRNA length base-pair 21 21
siRNA name in paper siYY5 siYY5
Biological activity 79 percent target mRNA inhibition
Experiment used to check activity FACS
Melting temperature (oC) NA
Target gene GFP gene
siRNA concentration 50 nM
Cell or Organism used HeLa cells
Transfection method Lipofectamine
Duration after transfection 48 Hours
Article title Synthesis and silencing properties of siRNAs possessing lipophilic groups at their 3'-termini
Reference18776474