| Field | Sense | Antisense |
| siRNA chemical modification | Tricyclodeoxyribonucleic acid | Tricyclodeoxyribonucleic acid |
| siRNA modification types | 1 | 1 |
| Overall number of modifications | 3 | 3 |
| Position of modifications | 10,20,21 | 11,20,21 |
| Modification on sugar or base or phosphate | Sugar | Sugar |
| SMILES (Click to view structure & nomenclature) |
OC1CCC2(O)CCOC12 |
OC1CCC2(O)CCOC12 |
| siRNA Sequence | GCAGCACGACUUCUUCAAGTT | CUUGAAGAAGTCGUGCUGCTT |
| siRNA length base-pair | 21 | 21 |
| siRNA name in paper | siTCSCSACS | siTCSCSACS |
| Biological activity | 80 percent target mRNA inhibition | |
| Experiment used to check activity | FACS and Real-time PCR | |
| Melting temperature (oC) | NA | |
| Target gene | EGFP gene | |
| siRNA concentration | 2 nM | |
| Cell or Organism used | HeLa cells | |
| Transfection method | Lipofectamine (Invitrogen) | |
| Duration after transfection | 42 Hours | |
| Article title | Improving gene silencing of siRNAs via tricyclo-DNA modification |
|
| Reference | 21687522 | |