| Field | Sense | Antisense |
| siRNA chemical modification | Altritol nucleic acid | 0 |
| siRNA modification types | 1 | 0 |
| Overall number of modifications | 4 | 0 |
| Position of modifications | 1,2,18,19 | 0 |
| Modification on sugar or base or phosphate | Sugar | 0 |
| SMILES (Click to view structure & nomenclature) |
OCC12COC(CO1)C2O |
- |
| siRNA Sequence | GUAUUGACAGCUAUUCGAATT | UUCGAAUAGCUGUCAAUACTT |
| siRNA length base-pair | 21 | 21 |
| siRNA name in paper | ORF1 2358 | ORF1 2358 |
| Biological activity | 53 percent target mRNA inhibition | |
| Experiment used to check activity | Flow cytometry assay | |
| Melting temperature (oC) | 71.5 | |
| Target gene | MDR1 gene | |
| siRNA concentration | 50 nM | |
| Cell or Organism used | NIH-3T3-MDR cells | |
| Transfection method | Lipofectamine 2000 | |
| Duration after transfection | 72 Hours | |
| Article title | Inhibition of MDR1 expression with altritol-modified siRNAs |
|
| Reference | 17264131 | |