| Field | Sense | Antisense |
| siRNA chemical modification | 0 | Altritol nucleic acid |
| siRNA modification types | 0 | 1 |
| Overall number of modifications | 0 | 1 |
| Position of modifications | 0 | 18 |
| Modification on sugar or base or phosphate | 0 | Sugar |
| SMILES (Click to view structure & nomenclature) |
- |
OCC12COC(CO1)C2O |
| siRNA Sequence | GUAUUGACAGCUAUUCGAATT | UUCGAAUAGCUGUCAAUACTT |
| siRNA length base-pair | 21 | 21 |
| siRNA name in paper | ORF1 2193 | ORF1 2193 |
| Biological activity | 76 percent target mRNA inhibition | |
| Experiment used to check activity | Flow cytometry assay | |
| Melting temperature (oC) | 67.3 | |
| Target gene | MDR1 gene | |
| siRNA concentration | 50 nM | |
| Cell or Organism used | NIH-3T3-MDR cells | |
| Transfection method | Lipofectamine 2000 | |
| Duration after transfection | 72 Hours | |
| Article title | Inhibition of MDR1 expression with altritol-modified siRNAs |
|
| Reference | 17264131 | |