SM3330 Chemically modified siRNA information

Field Sense Antisense
siRNA chemical modification 2-O-Methyl 0
siRNA modification types 1 0
Overall number of modifications 11 0
Position of modifications 19,21,23,25,27,29,31,33,35,37,39 0
Modification on sugar or base or phosphate Sugar 0
SMILES
(Click to view structure & nomenclature)
COC1C(O)OC(CO)C1O



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siRNA Sequence AUUCGUGCUCAUGGUGCACUUGUGCACCAUGAGCACGAAU 0
siRNA length base-pair 40 0
siRNA name in paper SG218 0
Biological activity NA
Experiment used to check activity Luciferase activity (MicroLumat LB 96P)
Melting temperature (oC) NA
Target gene Luciferase gene
siRNA concentration 20 nM
Cell or Organism used HEK293 cells
Transfection method Lipofectamine 2000
Duration after transfection 48 Hours
Article title Effects of chemical modification on the potency, serum stability, and immunostimulatory properties of short shRNAs
Reference19948766