| Field | Sense | Antisense |
| siRNA chemical modification | 2-O-Methyl | 2-O-Methyl |
| siRNA modification types | 1 | 1 |
| Overall number of modifications | 6 | 6 |
| Position of modifications | 3,6,8,10,17,18 | 4,5,12,14,16,19 |
| Modification on sugar or base or phosphate | Sugar | Sugar |
| SMILES (Click to view structure & nomenclature) |
COC1C(O)OC(CO)C1O |
COC1C(O)OC(CO)C1O |
| siRNA Sequence | GUCAUCACACUGAAUACCAAU | AUUGGUAUUCAGUGUGAUGACAC |
| siRNA length base-pair | 21 | 23 |
| siRNA name in paper | apoB-1 | apoB-1 |
| Biological activity | IC-50 = 1.5 nM for target mRNA | |
| Experiment used to check activity | ELISA | |
| Melting temperature (oC) | NA | |
| Target gene | Apolipoprotein B gene | |
| siRNA concentration | 0.6 to 45 nM | |
| Cell or Organism used | HepG2 cells | |
| Transfection method | Oligofectamine and Polyethylenimine (PEI) | |
| Duration after transfection | NA | |
| Article title | Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo |
|
| Reference | 16343994 | |