| Field | Sense | Antisense |
| siRNA chemical modification | 2-Deoxy-2-Fluoro* 2-O-Methyl | 2-Deoxy-2-Fluoro* 2-O-Methyl |
| siRNA modification types | 2 | 2 |
| Overall number of modifications | 21 | 21 |
| Position of modifications | 1,3,5,7,9,11,13,15,17,19,21 * 2,4,6,8,10,12,14,16,18,20 | 2,4,6,8,10,12,14,16,18,20 * 1,3,5,7,9,11,13,15,17,19,21 |
| Modification on sugar or base or phosphate | Sugar | Sugar |
| SMILES (Click to view structure & nomenclature) |
OCC1OCC(F)C1O COC1C(O)OC(CO)C1O |
OCC1OCC(F)C1O COC1C(O)OC(CO)C1O |
| siRNA Sequence | GGGUAAAUACAUUCUUCAUUU | AUGAAGAAUGUAUUUACCCUU |
| siRNA length base-pair | 21 | 21 |
| siRNA name in paper | ISIS 401156 | ISIS 401157 |
| Biological activity | NA | |
| Experiment used to check activity | NA | |
| Melting temperature (oC) | 20 | |
| Target gene | 0 | |
| siRNA concentration | 2.0 mM | |
| Cell or Organism used | HeLa cells | |
| Transfection method | NA | |
| Duration after transfection | NA | |
| Article title | Solution-state structure of a fully alternately 2'-F/2'-OMe modified 42-nt dimeric siRNA construct |
|
| Reference | 20624819 | |