SM3394 Chemically modified siRNA information

Field Sense Antisense
siRNA chemical modification 2-Fluoro* Deoxyinosine 0
siRNA modification types 2 0
Overall number of modifications 14 0
Position of modifications 4,5,6,7,8,9,10,11,12 * 1,2,13,14 0
Modification on sugar or base or phosphate Sugar 0
SMILES
(Click to view structure & nomenclature)
OCC1OCC(F)C1O
OCC1OC(CC1O)N1C=NC2=C1NC=NC2=O


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siRNA Sequence TTTGCGGUGGUUGCT AGAGACGCCACCAACCGUA
siRNA length base-pair 15 19
siRNA name in paper scL-HoKC-siRNA scL-HoKC-siRNA
Biological activity NA
Experiment used to check activity Real-time PCR
Melting temperature (oC) NA
Target gene HER-2 gene
siRNA concentration 100 nM
Cell or Organism used PANC-1 cells
Transfection method Injection
Duration after transfection 6 Hours
Article title Materializing the potential of small interfering RNA via a tumor-targeting nanodelivery system
Reference17409398