SM3399 Chemically modified siRNA information

Field Sense Antisense
siRNA chemical modification 2-O-Methyl 2-O-Methyl
siRNA modification types 1 1
Overall number of modifications 9 10
Position of modifications 2,4,6,8,10,12,14,16,18 1,3,5,7,9,11,13,15,17,19
Modification on sugar or base or phosphate Sugar Sugar
SMILES
(Click to view structure & nomenclature)
COC1C(O)OC(CO)C1O



COC1C(O)OC(CO)C1O



siRNA Sequence CCAACUUCACCAUCCAGAA UUCUGGAUGGUGAAGUUGG
siRNA length base-pair 19 19
siRNA name in paper CD31-1 CD31-1
Biological activity NA
Experiment used to check activity Real-time PCR
Melting temperature (oC) NA
Target gene Human PTEN gene
siRNA concentration 10 nM
Cell or Organism used PC-3, NIH3T3 cells
Transfection method Injection
Duration after transfection 48 Hours
Article title RNA interference in the mouse vascular endothelium by systemic administration of siRNA-lipoplexes for cancer therapy
Reference16625242