| Field | Sense | Antisense |
| siRNA chemical modification | 2-Fluoro* Cholesterol | 2-Fluoro* Cholesterol |
| siRNA modification types | 2 | 2 |
| Overall number of modifications | 10 | 3 |
| Position of modifications | 2,3,4,9,10,11,13,14,15 * 20 | 7,14 * 1 |
| Modification on sugar or base or phosphate | Sugar; Phosphate | Sugar; Phosphate |
| SMILES (Click to view structure & nomenclature) |
OCC1OCC(F)C1O CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C |
OCC1OCC(F)C1O CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C |
| siRNA Sequence | GCCUGGAGUUUAUUCGGAATT | TTCGGACCUCAAAUAAGCCUU |
| siRNA length base-pair | 21 | 21 |
| siRNA name in paper | NA | NA |
| Biological activity | NA | |
| Experiment used to check activity | Real-time PCR | |
| Melting temperature (oC) | NA | |
| Target gene | PCSK9 gene | |
| siRNA concentration | NA | |
| Cell or Organism used | HepG2 cells | |
| Transfection method | Lipofectamine 2000 | |
| Duration after transfection | 24 Hours | |
| Article title | Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates |
|
| Reference | 18695239 | |