| Field | Sense | Antisense |
| siRNA chemical modification | 2-O-Methyl* Phosphorothioate | 2-O-Methyl* 2-Fluoro* Cholesterol |
| siRNA modification types | 2 | 3 |
| Overall number of modifications | 21 | 8 |
| Position of modifications | 1,2,3,12,13,20,21 * 4,5,6,7,8,9,10,11,14,15,16,17,18,19 | 1,2 * 3,4,5,14,15 * 1 |
| Modification on sugar or base or phosphate | Sugar; Phosphate | Sugar; Sugar; Phosphate |
| SMILES (Click to view structure & nomenclature) |
COC1C(O)OC(CO)C1O OCC1OCC(O)C1OP(O)(S)=O |
COC1C(O)OC(CO)C1O OCC1OCC(F)C1O CC(C)CCCC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C |
| siRNA Sequence | GGACUUCUCUCAAUUUUCUTT | TTCCUGAAGAGAGUUAAAAGA |
| siRNA length base-pair | 21 | 21 |
| siRNA name in paper | 263 | 263 |
| Biological activity | NA | |
| Experiment used to check activity | Real-time PCR | |
| Melting temperature (oC) | 37 | |
| Target gene | Luciferase gene | |
| siRNA concentration | 20 mol/L | |
| Cell or Organism used | HeLa S3 cells and C57BL/J6 mice | |
| Transfection method | NA | |
| Duration after transfection | 72 Hours | |
| Article title | Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication |
|
| Reference | 15880588 | |