| Field | Sense | Antisense |
| siRNA chemical modification | 2-Deoxy-2-Fluoro | 2-Deoxy-2-Fluoro |
| siRNA modification types | 1 | 1 |
| Overall number of modifications | 3 | 3 |
| Position of modifications | 5,9,17 | 2,10,14 |
| Modification on sugar or base or phosphate | Sugar | Sugar |
| SMILES (Click to view structure & nomenclature) |
OCC1OCC(F)C1O |
OCC1OCC(F)C1O |
| siRNA Sequence | AGCCCAGAUAGCUCUUCAGTT | CUGAAGAGCUAUCUGGGCUTT |
| siRNA length base-pair | 21 | 21 |
| siRNA name in paper | 45-3A | 45-3A |
| Biological activity | 61 percent target mRNA inhibition | |
| Experiment used to check activity | Dual luciferase reporter assay | |
| Melting temperature (oC) | NA | |
| Target gene | Chimpanzee SOD2 gene | |
| siRNA concentration | 13 nM | |
| Cell or Organism used | HEK293 cells | |
| Transfection method | Lipofectamine 2000 | |
| Duration after transfection | 4 Hours | |
| Article title | Modified oligo-nucleic acid molecule, preparation method and uses thereof |
|
| Reference | US20120088815A1, EP2415869A1 | |