SM3990 Chemically modified siRNA information

Field Sense Antisense
siRNA chemical modification 0 2-O-Methyl
siRNA modification types 0 1
Overall number of modifications 0 1
Position of modifications 0 2
Modification on sugar or base or phosphate 0 Sugar
SMILES
(Click to view structure & nomenclature)
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COC1C(O)OC(CO)C1O



siRNA Sequence AGCGAUCCCGAACAAGUAUTT AUACUUGUUCGGGAUCGCUTT
siRNA length base-pair 21 21
siRNA name in paper 125-3B 125-3B
Biological activity 85 percent target mRNA inhibition
Experiment used to check activity Dual luciferase reporter assay
Melting temperature (oC) NA
Target gene Aspergillus AF293 protein
siRNA concentration 13 nM
Cell or Organism used HEK293 cells
Transfection method Lipofectamine 2000
Duration after transfection 4 Hours
Article title Modified oligo-nucleic acid molecule, preparation method and uses thereof 
Reference US20120088815A1, EP2415869A1